Analyse Of Recrudescent Related Risk Factors Of Graves Disease Patients Who Have Treated In Drug

Objective: Graves’ disease is an extremely common autoimmune thyroid disease. Application of antithyroid drugs which can effectively control the symptoms of Graves’ disease is the primary method for the treatment of Graves’ disease. However, there is a higher relapse rate after the treatment of antithyroid drugs. Investigating the recrudescent risk factors of Graves disease patients who have treated with drugs has a positive significance to reduces the relapse rate and improve the prognosis of patients.Methods: A total of 329 patients with Graves disease were selected. All patients were treated in the medicine of Propylthiouracil class and Methyl imidazole mainly. The patients of goiterandsevere exophthalmos were extra treated with thyroid tablets. The patients of sluggish liver were extra treated with bifendate or diammonium glycyrrhizinate, the patients of atrial fibrillation were extra treated with cedilanid and verapamil etc. The patients of leukopenia were extra treated with leucogen and diyu shengbai pian etc. According to the recurrence of patients, they were divided into recurrent group and no recurrent group. Collect the data of the two groups patients in detail, including the age of onset, gender, family history, degree of goiter, heart rate and the laboratory data of thyroid function(TSH, total T4, total T3, free T3, free T4, TRAb). Record whether the patients have exophthalmos, heart disease, myopathy, liver damage, leucopenia. The combination of above factors were compared between the two groups. The recurrence factors were verified with multiple liner stepwise regression analysis.Results: 329 cases of Graves’ disease patients after discontinuation of antithyroid drug had 140 cases of recurrence. The recurrence rate was 42.6%. Proportion of incidence age spreading<20 years old, The male proportion, proportion of more than second degree swelling, proportion of having family history, proportion of having exoph, proportion of having liver damage, proportion of having heart disease, proportion of having pretibial edema, proportion of having myopathy, and FT3 level, FT3/FT4 ratio, TRAb level were significantly higher than those of no recurrent group. The time of therapy, s TSH level were significantly lower than those of no recurrent group(P<0.05). The analysis showed that the factors of the age of onset, gender, family history, time of therapy, degree of goiter, FT3/FT4 ratio, TRAb, s TSH may be associated with the Graves’ disease recurrence. Multiple liner stepwise regression analysis showed that the factors of the incidence age, family history, degree of goiter, time of therapy, FT3/FT4 ratio, TRAb, s TSH are the risk factors in the Graves disease.Conclusion: The recurrence of graves disease are closely related with the incidence age, family history, degree of goiter, time of therapy, FT3/FT4 ratio, TRAb, s TSH.