| Objectives: Hypertension, shorter form for Essential Hypertension, is the main clinical manifestations of the high blood pressure syndrome. The prevalence and incidence rates differ in different countries, regions and ethnic. In our country the prevalence rate of the current adult hypertension is 18.8%, and the rate of the middle-aged population is 24%. The later period of high blood pressure diseases have severely threatened mankind’s health and life and seriously influenced the sufferer’s life span and life quality, for they can result in the damage of the organ such as heart, brain, kidney etc. thus the rates of disability and death rise very high. Heart attack and cerebral disease have been respectively listed as the first and the third death reason among the crowd over 40 years old in our country, whereas the first dangerous factor of the total death is a high blood pressure. How to safely and effectively prevent and cure a high blood pressure disease is the main concern of the sufferer and also one of the main topics that the clinical doctor studies. Studies show that Chinese herbal and western medicine’s uniting application can even strengthen body’s sensitivity to blood pressure lowering medicine and reduce the organ damages so as to obtain the best curative effect instead of using Chinese herbal medicine or western medicine alone. This paper discusses the effect of treatment of hypertension and clinical application by way of Bushenhuoxuehuayu clinical research.Methods: The general conditions of these two groups were not statistically different when 80 patients who met the inclusion criteria were randomly divided into two groups of clinical observation. Western group of 40 patients were given valsartan capsules(Amlodipine, Pfizer Pharmaceutical Co., Ltd. Zhunzi H10950224), each 5mg, once daily oral; In group Western and Chinese combined, totally 40 patients received Huatantongluohuoxuefang one dose per day, Orally twice a day morning and night hours; While taking valsartan capsules, each 5mg, once daily oral; treatment for 4 weeks. Two groups of patients were diagnosed by Western medicine are essential hypertension, Chinese dialectical belong to the phlegm and blood stasis type. Observation period, all patients stop taking drugs that affect blood pressure. Before and after the treatment the patients have been given a second security check. During the treatment, the changes of the patients are all observed, including vital signs, blood pressure, clinical symptoms and blood lipids, blood glucose, C-reactive protein, blood rheology, Renin,AngiotensinⅡ, and other related indicators of the changes.Results:1 Comparison of changes of blood pressure between the two groupsThere were no significant differences between the two groups before treatment(P>0.05). The systolic and diastolic blood pressure in the two groups after treatment than before treatment are lower, and the difference is significant(P<0.01); Do the two groups after treatment compared with systolic and diastolic blood pressure, lower blood pressure in group Western and Chinese combined, there is a significant differences(P<0.05); In group Western and Chinese combined, blood pressure shows a continued, steady decline, and declined more than simple western medicine group, it proves that the antihypertensive effect of blood pressure of Huatantongluohuoxuefang group is more effective than western medicine alone group.2 Comparison of the average value of ambulatory blood pressure between the two groups before and after treatmentBefore treatment, the average value of systolic and diastolic blood pressure between the two groups show no significant difference(P>0.05); After treatment compared with before treatment, both groups show significant difference(P<0.05); After treatment, the average value of systolic and diastolic blood pressure in group Western and Chinese combined is better than that in western medicine group, there is significant difference(P<0.05). It shows that the antihypertensive efficacy of Huatantongluohuoxuefang group is better than western medicine alone group.3 Comparison of the effect on lowering blood pressure between the two groupsIn group Western and Chinese combined, there are markedly 28cases(70.00%), effective 10 cases(25.00%), ineffective 2 case(5.00%), the total effective rate is 95.00%; in western group, there are markedly 26cases(65.00%), effective 6 cases(15.00%), ineffective 8 cases(20.00%), the total effective rate is 80.00%. Comparing the total efficiency of antihypertensive effects of the two groups, the difference is significant(P<0.05). It shows that the antihypertensive efficacy of Huatantongluohuoxuefang group is better than western medicine alone group.4 Comparison of the clinical effect between the two groupsIn group Western and Chinese combined, 30 cases are markedly(75.00%), 6 cases are effective(15.00%), 4 cases are ineffective(10.00%), total efficiency is 90.00%; in western group, 10 cases are markedly(25.00%), 16 cases are effective(40.00%), and 14 cases are ineffective(35.00%), the total effective rate is 65.00%. Upon examination, the two groups to improve the total efficiency of clinical symptoms are significantly different(P<0.01). It shows that Huatantongluohuoxuefang group therapy in improving clinical symptoms is better than western medicine alone group.5 Comparison of blood glucose and blood lipid between the two groups before and after treatmentIn group Western and Chinese combined, blood glucose, cholesterol, triglycerides, low density lipoprotein, are significantly lower than before treatment(P<0.05), Do the two groups after treatment compared with blood glucose and blood lipid, there is a significant differences(P<0.05); Although there are some changes in various indicators of western medicine group after treatment than before treatment, but it is no significant difference. It shows that the treatment effects in promoting glucose metabolism and improving lipid metabolism, Huatantongluohuoxuefang group is more effective than western medicine alone group.6 Comparison of blood rheology between the two groups before and after treatmentIn group Western and Chinese combined, after treatment compared with before treatment, whole blood viscosity and fibrinogen decreased significantly(P<0.05), and after treatment, Fibrinogen comparing with the western medicine group are significantly different(P<0.05), changes in other indexes have no statistical significance. In western medicine group, although there is a change for the values after treatment than before, but it is no statistically significant. It shows that Huatantongluohuoxuefang group has better effect of reducing blood viscosity than western medicine alone group.7 Comparison of C-reactive protein between the two groups before and after treatmentBefore treatment, C-reactive protein between the two groups showed no significant difference(P>0.05); after treatment than before, both groups showed significant difference(P<0.05); after treatment, C-reactive protein are significantly lower than western medicine group, and it is significantly different(P<0.05). It shows that Huatantongluohuoxuefang group has better effect of reducing C-reactive protein than western medicine alone group.8 Comparison of the renin, angiotensinⅡbetween the two groups before and after treatmentBetween the two groups before treatment, renin, angiotensin Ⅱdetermination are no significant difference(P>0.05); After treatment compared with before treatment, in group Western and Chinese combined it significantly decreased, and it is significantly different(P<0.05); in western medicine group it increased significantly, and it is a significant difference(P<0.05).After treatment between the two groups are significantly different(P<0.01). It shows that Huatantongluohuoxuefang group could significantly reduce plasma renin, angiotensin Ⅱ secretion, inhibits renin activity and angiotensin Ⅱ generation.9Adverse reactionsIn western group of 40 patients, only 2 patients had mild ankle edema, and could be tolerated; two groups found no damage to liver and kidney function and other adverse reactions.Conclusion:The clinical study results show that Huatantongluohuoxu efang has obvious effect for essential hypertension.1 Huatantongluohuoxuefang has a positive effect on the phlegm and blood stasis type of hypertension, antihypertensive effect is superior to western medicine alone.2 Comparison with the results of valsartan alone, confirm that the Chinese combined with western medicine group in improving clinical symptoms of hypertension,(such as dizziness, headache, backache knee soft and so on) and reducing risk factors(such as blood glucose; blood lipids and so on) is better than western medicine group.3 Huatantongluohuoxuefang--blood pressure mechanism may reduce the blood viscosity by improving lipid metabolism, and promote glucose metabolism, lower C-reactive protein and renin, angiotensinⅡ, inhibit renin activity and angiotensin Ⅱ generation and other factors to achieve. These factors contribute to the positive effect on controling of the occurrence, development of hypertension and the complications thereafter effectively lower blood pressure and improve clinical symptoms of hypertension. |
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