| Purpose: With the rapid development of China’s construction, transportation and other areas in recent years, fall injury, bruise, injury accident rate increased year by year, resulting orthopedic disorders increasing year by year trend. Traumatic orthopedic diseases with open reduction and fixation on conventional surgical approach based. Because healing takes 6-8 weeks or even 12 weeks, with joint activities and time limit will be increased due to complications supine. In recent years, the development of biomechanical research and internal fixation technology allows most current fracture reduction can achieve another satisfactory degree, but after braking caused by stiff joints, lung infections and other issues have become fracture prognosis an important reason. Therefore, how to shorten the course of orthopedic diseases and shorten the braking time in bed, thereby reducing the incidence of complications and sequelae gradually become key issues of domestic and foreign orthopedic research.Salvia Drug traditional Chinese medicine, mainly by tanshinones and phenolic acids composition of its active ingredient, has been widely used in clinical Salvia preparations. Some data indicate that Salvia can effectively promote healing by improving blood supply to the fracture site, enhanced fracture adjacent parts of calcium mobilization, promotion of osteoblasts, osteoclasts in bone matrix formation, calcification and shaping the functional enhancement promoting calcification of the fracture fragments.This study was to salvianolate injection compression fractures of thoracolumbar spinal canal decompression surgery.Efficacy cord injury functional recovery, Shenxiong glucose prevention of fractures fixation skin flap necrosis clinical application, resume preparation Salvia explore the role of therapy in postoperative orthopedic diseases, as Dan Shen agents in fracture sick kind Governance provide the basis for clinical application.Method: 1 Salvianolate compression fractures of the thoracolumbar spinal decompression functional recovery after spinal cordThrough different clinical trauma caused by the treatment of 260 cases of thoracolumbar compression fracture efficacy in patients with varying degrees of spinal cord injury after comparing observed salvianolate efficacy of postoperative functional recovery. 1.1 Grouping:Thoracolumbar compression fracture patients(cases from the Third Hospital of Hebei Medical University First Hospital trauma center and orthopedic Xinji City, Hebei Province), were randomly divided into two groups of 120 patients treated 140 cases in the control group. Patients treated with 76 males and 64 females, aged 31 to 69 years, with an average age of 40.6 years. The main damage segments of patients was: T11: 37 cases, T12: 41 cases, L1: 50 cases, L2: 12 cases. The main reason for the patient’s injury: traffic accident 60 cases, by falling in 57 cases, 23 cases of heavy impact. The control group of patients 66 males and 54 females, aged 33 to 65 years, with an average age of 39.8 years. The main damage segments of patients was: T11: 32 cases, T12: 41 cases, L1: 40 cases, L2: 7 cases. The main reason for the patient’s injury: traffic accident 46 cases, by falling in 47 cases, 27 cases of heavy impact. All enrolled patients with varying degrees of spinal cord injury(ASIA damaged graded according to all patients diagnosed with spinal cord injury and recorded score, which treated 37 cases of grade A, grade B 41, C in 55 cases, D grade seven cases, E Level 0 cases; 31 cases in the control group A-level grade B 32, C in 49 cases, D grade 8 cases, E grade 0 cases). Treatment of patients with lower extremity muscle strength in patients were abnormal, of which 72 cases of lower extremity muscle strength completely noninvasive, bloating, incontinence were 134 cases; the control group of patients were abnormal lower extremity muscle strength, lower extremity muscle strength which is completely noninvasive 68 cases, with abdominal distension, 112 cases of incontinence. Both groups were sex, age, duration, injured segments, as well as spinal cord injury Injury grading and other general information was no significant difference in comparison(P>0.05), comparable. 1.2 treatment and drugs:All patients after admission methylprednisolone pulse therapy, in 48 h after injured spinal decompression routine open reduction internal pedicle screw fixation, both preoperative and postoperative 24 h routine use of antibiotics to prevent infection, postoperative treatment group Salvianolate injection. Salvianolate injection is the main component of Salvia acid. Usage and consumption: intravenous drip. Once 200 mg, was dissolved after a 0.9% sodium chloride injection 250ml-500 ml use. 1 time a day. Course of 10-14 days. The control group was 0.9% sodium chloride injection 250ml-500 ml. 1 time a day. Course of 10-14 days. 1.3 Adverse reactions:All patients in 4 patients after treatment mild allergic reaction subsided after anti-allergy treatment. 2 cases of gastrointestinal irritation, after oral administration of omeprazole symptoms disappear. 1.4 Evaluation:According ASIA neurological classification of spinal cord injury with international standards(ISNCSCI) patients before and after surgery for sensory / motor function score according to the characteristics of the statistical classification damaged ASIA classification. 1.5 Statistical Methods:Statistical treatment group and control group score difference before and after surgery, t-test, P<0.05 was considered statistically significant. Statistics groups before and after surgery ASIA AIS grade level(two-sample variance arrhythmia), were rank test, P<0.05 considered statistically significant. 2 Shenxiong glucose prevention calcaneal fracture fixation skin flap necrosis clinical effectObservation of 60 cases of fresh fractures in patients(cases from the Third Hospital of Hebei Medical University First Hospital trauma center and orthopedic Xinji City, Hebei Province) after internal fixation of the recovery process of wound healing of various treatments, and to explore Shenxiong glucose prevention calcaneal fracture surgery skin flap necrosis applications. 2.1 Grouping60 cases of fresh fractures of the calcaneus(injury to hospitalization operation time<7days) hospitalized patients were randomly divided into 2 groups(excluding open fracture patients, with spinal injuries, diabetes and other diseases, basal metabolism). All patients identified as type IV according to Sanders classification. Treatment group of 30 patients: 17 males and 13 females; aged 18 to 63 years, mean 32.8 years; duration of 12d~14d, an average of 13d; injury factors: altitude fall injury in 14 cases, traffic accident in 9 cases, 7 cases of heavy impact. The control group of 30 patients, 19 males and 11 females; aged 19 to 65 years, mean 36.1 years; duration 12d~15d, an average of 13.2d; injury factors: altitude fall injury in 11 cases, 10 cases of car accidents, heavy impact 9 cases. 2.2 treatment and drugsAll patients after admission to operation forward limb elevation, mannitol swelling, 48 h after injury adopt open reduction and internal fixation of calcaneal titanium are routine use of antibiotics to prevent infection in the preoperative and postoperative 24 h, surgery After the treatment group Shenxiong glucose injection(Jilin Pharmaceutical Co., Ltd. four long Zhunzi) 100 ml intravenous infusion, 2 times a day. 100 ml glucose control group intravenous injection twice daily. 2.3 Clinical StandardsWound healing grading refer to "Huang Si surgery" relevant diagnostic criteria [2]: Class Healing: The A stands for, referring to heal fine, no adverse initial healing; B Healing: The B stands for means poor healing, symphysis inflammation reactions, such as redness, induration, hematoma, effusion, but fester; Grade C union representatives with the prop word refers to fester incision needs to be done incision and drainage or crusting. Evaluation: Class markedly, B is valid, Class C or non-healing wounds, skin flap necrosis as invalid.Group to monitor whether the allergy treatment, gastrointestinal reactions, etc; underwent preoperative blood, coagulation, biochemistry full term examination, the treatment group and the presence or absence of coagulation dysfunction glucose. 2.4 Statistical Methods:Application SPSS13.0 statistical software for data t test, rank sum test, treatment efficiency compared using χ2 test.Results1 Patient before and after surgery sensory / motor function score results showed that after application salvianolate, postoperative score was significantly higher than that before operation(22.51±4.12), whereas no significant improvement in the control group scores(15.35±4.89), P<0.05. ASIA damaged outline salvianolate treatment group lower extremity nerve function improvement was statistically significant compared to the control group. The results suggest that salvianolate promotes traumatic thoracolumbar compression fractures in patients with postoperative recovery, shorter braking time a patient.2 Classification of wound healing showed that, after applying Shenxiong glucose injection, blood supply and improve wound treatment group was significantly higher efficiency. Preoperative coagulation examination, the full results of biochemical groups were normal. The results suggest that Shenxiong glucose injection can significantly improve postoperative wound healing, prevention of skin flap necrosis has a positive effect.Conclusion: Application by the efficacy of two formulations comparative study between two different orthopedic diseases are Salvia, Salvia confirmed application formulation effectively improve the clinical symptoms and shorten the hospital stay and braking time, reduce complications, reduce the the majority of patients with pain, and fewer side effects, safe and effective, with good economic and social benefits, should be widely applied. |
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