The Plasma Cortisol And Its Influence On Short-term Prognosis In Chronic Heart Failure

Objective:To survey the plasma cortisol and its influence on short-term prognosis in heart failure.Method:We collected data of clinical characteristics, cortisol, uric acid, creatinin, Ccr, cystatin, SCys C-Ccr, LVEF, BNP, hs CRP, PRA, angiotensinâ… , angiotensinâ…¡ and ALD in 192 unselected patients with congestive heart failure. Correlations between cortisol levels and uric acid, creatinin, Ccr, cystatin, SCys C-Ccr, LVEF, BNP, hs CRP, PRA, angiotensinâ… , angiotensinâ…¡, ALD and NYHA were analyzed using Spearman correlation. The all-cause mortality was followed up in two groups after 6 months.Results:The difference in cortisols had statistical significance between four subgroups(P < 0.05). There was a significantly inverse correlation between Ccr, SCys C-Ccr and cortisol, while there was a significantly positive correlation between uric acid, creatinin, cystatin and cortisol. After following up for 6 months, the cardiovascular events morbidity of high cortisol group was 47.3%, which was significantly higher than that in low cortisol group(29.5%, P<0.05). The mortality was 18.9% in high cortisol group, which was significantly higher than that in low cortisl group(9.52%, P<0.05). The survival analysis of Kaplan-Meier showed that the survival rate was significantly higher in low cortisol group than that in high cortisol group(P<0.05) during follow-up period.Conclusions : The high plasma cortisol levels were significantly correlated to cardiac function and renal function in patients with chronic heart failure, the increase of cortisol density may lead higher mortality in CHF patients.