The Clinical Observation On The Treatment Of Liver And Kidney Syndrome Of Deficiency Knee Osteoarthritis With Kangguzengsheng Pills

Objective:To observe the clinical effect of the treatment on Liver and kidney deficiency syndrome of knee osteoarthritis with Kangguzengsheng pills.This study can provide a theoretical basis for the drug in the clinical application.Methods According to the inclusion and exclusion criterion,59 patients diagnosed with e arly liver and kidney deficiency knee osteoarthritis were selected from Orthopedic outpatient of Quanzhou TCM Hospital.The patients were randomly divided into two groups treatment gr oup and control group.There are 30 cases in treatment group and there are 29 cases in control group.In control group,Celecoxib was taken orally at 200 mg, once a day,including 9 males and 20 females,with an average age of 57.10 years(range,51-64 years) and an average course of disease of 8.07 months(range,3-15 months).The treatment lasted for 4 weeks.In treatment group, Kangguzengsheng pills were taken orally one dosage,2 times a day,including 8 males and 22 females,with an average age of 58.90 years (range,50-65 years) and an average course of disease of 8.33 months(range,2-18 months).The treatment lasted for 4 weeks.There was no statistical difference between the control group and the treatment group(P>0.05). The therapeutic effect of traditional Chinese Medicine,Pain degrees and the WOMAC knee-Rating Scale were used for evaluation prior to treatment and 4 weeks after treatment. The content of NO in joint fluid was determined by nitrate reductase assay prior to treatment and 4 weeks after treatment,and to summary the treatment effect.Results:There was statistically significant difference between before and after treatment in the same group(P< 0.05).There was no significant difference after the treatment between the two groups.The main results were as follows:①The VAS score of the treatment group was (4.93±0.69) while the control group was (5.04±0.67) before the treatment;and the VAS score of the treatment group was (1.79±0.96) while the control group was (1.56±0.77) after the treatment.There was no significant difference after the treatment between the two groups(P< 0.05).②The WOMAC score of the treatment group was (107.30±9.72) while the control group was (108.69±10.12) before the treatment;and the VAS score of the treatment group was (37.47±23.71) while the control group was (32.10±18.89) after the treatment.There was no significant difference after the treatment between the two groups(P< 0.05).③According to the therapeutic effect of traditional Chinese Medicine from 《Criteria of diagnosis and therapeutic effect of diseases and syndromes in traditional Chinese medicine》,6 cases were obviously effective,20 cases were effective and 4 case is invalid in the treatment group,and the rate of effective cases was 86.7%,while in the control group,5 case was obviously effective,22 cases were effective and 2 cases were invalid,the rate of effective cases was 93.1%.No significant difference was found between the treatment group and control group.④The NO content of the liquid of the treatment group was (57.18±8.26)μmol/L while the control group is (59.62±6.64)μmol/L before the treatment;and the NO content of the liquid of the treatment group was (57.18±8.26)μmol/L while the control group was (38.66±6.86)μmol/L after the treatment.There was no significant difference after the treatment between the two groups(P<0.05).Conclusion:It is exact curative effect on liver and kidney deficiency syndrome of knee osteoarthritis with Kangguzengsheng pills.