Effects Of Compound Tablet BUJIN For Osteoarthritis In Postmenopausal Hormone Plasma Cytokine

Objective:Observation compound tablet BUJIN treatment for postmenopausal the curative effect of knee osteoarthritis and to explore its in postmenopausal patients with knee osteoarthritis intervention effect of sex hormone and cytokine in plasma.Methods:In November 2010 to March 2013 qualified in orthopedics outpatient clinic in postmenopausal patients with knee osteoarthritis 60 cases, treatment group 30 cases, aged 45 to 75, an average of 55 years old; Course 1-24 months, average 10.07 months; One knee pain in 19 cases, the double knee pain in 11 cases. Control group 30 cases, aged 45 to 75, an average of 54 years old; Course 1-24 months, average 9.83 months; One knee pain in 20 cases,10 cases of knee pain, fill (compound tablet BUJIN group) were randomly divided into test group and control group (Zhuangguguanjie pill group). Treatment group was given compound muscle piece, three times a day,4/times, suit with lukewarm water after a meal; The control group given strong bone joints, pills, two times per day,6 g/times, morning and evening with warm water after a meal. Continuous treatment of 4 weeks, the two groups were treated with other drugs during treatment or cure. Records of patients during treatment with and without discomfort, respectively ended before taking the medicine and treatment to patients within 1 week of VAS score evaluation, ISO A, symptoms and signs and take patients with venous blood and joint fluid and serum estradiol, testosterone, and joint synovial fluid and plasma IL-1 beta, TNF alpha test.Results:(1) Two treatment methods can make the postmenopausal patients with knee osteoarthritis clinical symptoms integral, two groups of comparison, VAS pain score was no significant difference (P>0.05), ISOA signs and symptoms score, score more significant differences (P<0.05), compound tablet BUJIN group in improving clinical symptoms than Zhuangguguanjie pill group; (2) After treatment of 4 weeks, fill compound tablet BUJIN group total effective rate 83.3%, Zhuangguguanjie pill group total effective rate 80%. By chi-square test, P< 0.05, compound tablet BUJIN group curative effect is superior to the Zhuangguguanjie pill group; (3) The two treatment methods can make the venous blood in postmenopausal patients with knee osteoarthritis higher oestrogen and testosterone, IL-1 beta in venous blood and joint fluid, reducing the TNF alpha and comparison, the two groups have significant difference (P＜0.05).Conclusion:(1) The compound repair reinforcement can obviously improve clinical symptoms in patients with or cure, at the same time make patients with knee pain degree of ease or painless, fill that compound tablet BUJIN is an effective method for treatment of knee osteoarthritis after menopause. (2) In patients with venous blood estradiol, testosterone values in different degree, and the fluid of the patients with venous blood and joint IL-1 beta and TNF alpha to varying degrees, reducing, and with the patient’s clinical symptoms was significantly positive correlation, estradiol, testosterone, IL-1 up TNF alpha and beta may be postmenopausal occurrence and development of the important reasons for knee osteoarthritis; (3) By detecting venous blood estradiol and testosterone value before and after the treatment, and venous blood and joint fluid IL-1 beta, TNF alpha explanation:the mechanism of action of compound tablet BUJIN group take effect may be related to sex hormones and cytokines.