The Clinical Characteristics Of Bone Metastases And The Clinical Study Of Radiotherapy Controlling Bone Pain

Objective: This study analyze the clinical features of metastatic bone tumors and explore the therapeutic effect of radiotherapy on pain caused by bone metastases,which in order to better improve the life quality of malignant tumor patients with bone metastases.Methods: Clinical characteristics and the recent curative effect of all 112 cases of malignant tumor patients with bone metastases were retrospectively analyzed, using different segmentation scheme according to the systemic conditions and pathological changes positions, a set of 30Gy/10 fx radiation dose was designed, another group received a 40Gy/20 fx radiation dose.Results: Metastatic bone tumors occur the most frequently in patients over 40 to 80 years old. The most commonly sites of origin include the lung cancer mainly in males,breast cancer mainly in females and so on. The predilection sites of bone metastases are the spine, ribs, pelvis, femur, and sternum. Different degree of pain was the most common clinical manifestation of patients with bone metastases(86.1%), and few patients suffered with local swelling, dysfunction, pathologic fracture and paraplegia as the main clinical manifestations, only 13.9% patients with primary focal symptoms were later diagnosed with bone metastases. The imaging examinations were most demonstrated issolved osseous lesions(79.3%), few patients with varying degrees of elevated alkaline phosphatase(16.7%).Different segmentation schemes were used according to the systemic conditions and pathological changes positions, in total of112 patients with bone metastases, 82 people received a 30Gy/10 fx radiation dose,another 30 patients received a 40 Gy/20 f x radiation dose.32.9%(27/82) patients received 30Gy/10 fx dose acheive complete remission, 63.4%(52/82)partial remission,and the inefficiency accounted for 3.7%(3/82). 46.7%(14/30) of the patients who received 40Gy/20 fx dose acheive complete remission, 50.0%(15/30)acheive partial remission,and the inefficiency accounted for 3.3%(1/30). Theeffective rate of 30Gy/10 fx group was 96.3%, while effective rate of 40Gy/20 fx group was 96.7%, which shows no statistical significant differences in the two groups(P =0.187).Conclusion: Pain is the most common clinical manifestations of bone metastases.Radiation therapy plays a very important role in the treatment of bone metastases pain.Palliative radiotherapy can not only effectively reduce the pain of patients with symptoms, and could kill some malignant tumor cells, improve terminal cancer patients’ quality of life and prolong survival.