| Abstract:The pain of bone Metastasis is a kind of complicated pathogenesis and unique pain status, seriously affecting the quality of life of patients with advanced cancer. Therefore, active treatment of bone metastasis pain has become one of the key of the cancer treatment. Clinicians should be to alleviate and control cancer pain for the purpose, multidisciplinary collaboration, to alleviate the suffering of patients, improve the quality of life of patients, prolong the survival time of patients. AT present, drug treatment, has become the main Methods to be used in the treatment of bone metastasis pain, the main use of Opioids, Bisphosphonates, Calcitonin. Radionuclide therapy, and radiotherapy, chemotherapy, endocrine therapy, molecular targeted therapy, thermotherapy method. Thermotherapy has a long history, according to a large number of literature research, hyperthermia has not only directly effect on tumor cells, but also can enhance the efficacy of chemotherapy and radiotherapy, traditional Chinese medicine, improve immunity, inhibit tumor metastasis, especially with reliable good curative effect on the treatment of the cancer pain. of metastasis bone Traditional Chinese medicine and in combination with hyperthermia can promote absorption and penetration of drugs to tumor cells, accelerate the reaction speed. Thus the intracel lular concentration of drug increased, in order to achieve the greatest synergism. Traditional Chinese medicine combined with hyperthermia for the treatment of malignant tumor, has positive clinical significance, is worthy of further study.Research objective:At the hospital level program "Zi yin Bu Shen method to improve on quality of life in cancer patients with bone metastasis tumors of (number:2007-01)"[12-16]:"Fuzheng Huayu" confirmed the effect of "Yishen Gukang" treatment group, stable lesion was significantly higher than that treated with western medicine alone bone metastasis, and significantly improve the kidney yin deficiency deficiency, blood stasis symptoms, The score of KPS increase stability higher than that of the control group, the NRS pain score was significantly lower than before treatment. Wangjing Hospital oncology in2009approved the Ministry of finance support, the purchase of SR1000Ⅱ radiof requency thermotherapy machine, its principle is to use physical method to kill tumor cells of tissue heating temperature (42.5℃-43.5℃) for60to120minutes, to destroy tumor cells and normal tissue is not injured (temperature safety margin normal tissues cells was45±1℃) method.On the basis of previous studies, further confirmed the efficacy of hyperthermia in the treatment of metastasis bone pain with Chinese medicine, safety and strictly observed and hyperthermia; to investigate the possible mechanism of traditional Chinese medicine combined with hyperthermia in the treatment of cancer pain of bone metastasis; of traditional Chinese medicine combined with hyperthermia intervention during Opioid drugs decrement and efficacy by science; the evaluation method and system, to explore with Chinese characteristics, specification, clinical curative effects of cancer therapy.Research methods:The randomized study, a total of40patients with metastatic bone cancer pa in. The control group oral oxycodone and acetaminophen tablets (Tylox) oxycodone hydrochloride5mg and paracetamol in test group0.325g, oral administration of oxycodone and acetaminophen basis, oral administration of traditional Chinese medicine "YiShenGukang"1/day and in pain at the site of radiofrequency hyperthermia2times/week,14days are1treatment course of treatment, the end after the evaluation. Assessment scale, frequency of breakthrough pain, patient dose evaluation of the clinical efficacy of using the NRS method, the KPS score, pain assessment scale to observe the quality of life of the patients.Results:Pain control was better than the control group after treatment (P<0.05), the number of outbreaks of pain is lower than that in control group (P<0.05), acetaminophen tablets (Tylox) was significantly reduced compared with the control group (P<0.05), the effects of pain score decreased significantly (P <0.05), but the two groups before and after treatment KPS score had no significant difference (P>0.05). Conclusion:the kidney Gukang combined with hyperthermia in treatment of patients with bone metastasis of cancer pain can effectively enhance the analgesic effect, and can reduce opioid dosage, and can effectively improve the quality of life of patients, however, the physical condition of patients to improve the problems still exist. |
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