Risk Factors Of Recurrence In401Patients With Ischemic Stroke

Objective To investigate the related risk factors of the recurrence ofischemic stroke and to provide basis for its prevention and cure.Methods Summary analysis clinical data of401cases ischemic stroke inCardio-cerebral Vascular Disease Hospital of Ningxia Medical UniversitySeptember2011to September2012,(This study selected424cases onset ofischemic stroke in Ningxia.Through hospitaltreatment,patients were discharged.According to the patient’s diagnosis of disease and condition chose medicine. Allpatients were asked to take medicine regularly.Without contraindications,patientswere given sapirin antiplatelet aggregation and other treatments for secondaryprevention.Completed1-year follow-up,lost23cases,Finally acquired clinical dataof401cases).According to relapse in one year divided into recurrence group andnon-recurrence group, we collected and abstracted related clinical data.Theseclinical data can be obtained through hospital registration records,outpatientreexamination,1-year regular review, telephone follow-up and so on. Including sex,age, family history of stroke, hypertension, history of TIA, diabetes, smoking,drinking, coronary heart disease, atrial fibrillation, carotid artery plaque,hyperhomocysteinemia and hyperlipemia. Recurrence group including79recurrentcases and non-recurrence group including322non-recurrent cases.The information has been obtained were analyzed by the chi-square test andmultivariate Logistic regression.Results According to results of Chi-square test, sex（X2=4.246,P=0.039）,age（X2=11.660, P=0.001）,hypertension（X2=13.813, P<0.05）,diabetes（X2=32.427, P<0.05）,smoking（X2=5.421, P=0.029）,coronaryheart disease （X2=6.964, P=0.008）,family history of stroke （X2=5.529,P=0.022）,history of TIA （X2=7.019, P=0.010）,atrial fibrillation（X2=7.674,P=0.009）,hyperhomocysteinemia（X2=35.930, P<0.05）,hyperlipemia（X2=5.530,P=0.027）,carotid artery plaque（X2=68.054, P<0.05）.Differences were statisticalsignificance.Associated with recurrence of ischemic stroke closely. This showsthat male,age≥60years old,hypertension,diabetes,smoking, coronary heartdisease,family history of stroke,history ofTIA,hyperhomocysteinemia,hyperlipemia,carotid artery plaque are the risk factorsof the recurrence of ischemic stroke. Multivariate logistic regression shows thatdiabetes:OR=3.728,(1.588-8.753)95%CI,P<0.05;hyperhomocysteinemia:OR=2.858,(1.280-6.383)95%CI, P<0.05;carotid arteryplaque:OR=15.346,(4.355-54.079)95%CI, P<0.05).Diabetes,hyperhomocysteinemia and carotid arteryplaque are the independent risk factors of the recurrence of ischemic stroke.Conclusion1.This study reveals that diabetes,hyperhomocysteinemia andcarotid artery plaque are independent risk factors of recurrence of the ischemicstroke.2.Male,age≥60years old,hypertension,smoking,family history of stroke,coronary heart disease,diabetes,history of TIA,atrial fibrillation,hyperhomocysteinemia,hyperlipemia and carotid artery plaque are the risk factors of the recurrence of ischemic stroke.3.Effective intervention is of greatsignificance to controlling the recurrence of ischemic stroke.