| Objective：1discussed the status of obesity in children and adolescents, NingXia Huiand Han areas, to accelerate the deployment of a variety of active preventive measures, makeevery effort to control, delay, deter childhood obesity pandemic in the NingXia region.2Ghrelin gene polymorphism exists in the difference between the return of Han children andadolescents, as well as the relationship between obesity and children, to further clarify theGhrelin gene in obese children and adolescents and Han role.Methods：Stratified cluster sampling, randomly selected in Guyuan City, Wuzhong Citywere elementary, middle and high school each one, Yinchuan eight randomly selectedelementary, middle and high school all three totaling20. Against being drawn by grade schoolstratified cluster sampling, elementary grades1-5(except for sixth grade) all four classes. Ajunior, sophomore, high school, grade eight classes each extraction, totaling14,272people.Research on the selected object height, weight, waist circumference, hip circumference, bloodpressure. According to Chinese screening overweight and obesity in children and adolescentsBMI classification criteria, screening out obesity, overweight children, while selecting thesame sex, normal weight children of the same age, the informed consent of its release, thesigning of the informed consent of students fasting venous blood, blood biochemicalparameters measured, measured Ghrelin gene rs26802, rs42451, polymorphism rs696217,rs27647sites while using Sequenom mass spectrometry.Results：The baseline survey of14,272people, including boys and7206, female7066people,10331people of Han, Hui3782people,160people of other nationalities.1) overweight, obesity, abdominal obesity overall detection rate of11.7%, respectively. 8.4%,14.9%. Boys obesity, overweight detection rate was10.3%,13.2%, respectively, ofgirls obese, overweight detection rate was6.5%, respectively,10.1%, overweight, obesity,boys> girls, boys and abdominal obesity were14.4%detection rate,15.4%, female> male.2) the highest incidence of obesity boys ages8,9,10three age groups in their obesity rateswere15.5%,15.8%,15.0%, with increasing age age group decreased their rates of obesity,overweight boys age group rate of13.2percent, the highest incidence in the age group8,11-year-old son, whose overweight rate was17.3%,18.6%, respectively. female obesity werehighest in the age group of8-year-old age group, obesity was11.6%. With increasing age,obesity rates in the age group gradually decreased, but the obesity rate and significantlysmaller than boys the same age. Girls age group of children and adolescents are overweightwas10.1percent, the highest incidence in16,17,18three age groups were12.2%,12.0%,14.3%of girls are overweight rates increased with age but increased.3) boys abdominal obesity was14.4%, the highest incidence in the age group between8to13years old abdominal obesity rates were15.7%,16.1%,17.0%,16.3%,18.6%,15.3%,other age segments are maintained at a relatively stable rate of girls abdominal obesity rate of15.4%, its incidence increases with age increased incidence of abdominal obesity, its largestage group in18years.4) different ethnic obese children and adolescents, overweight detection rate were higherthan Han Hui, the difference was statistically significant (χ2=31.35p=0.000). Back to theHan children and adolescents with abdominal obesity rates were12.0%,16.2%, thedifference was statistically significant (χ2=13.48p=0.000). Body mass index, abdominalobesity different detection rate of obese> overweight> normal group, the detection rate was66.1%,55.7%and4.7%. The difference was statistically significant (χ2=5382.9p=0.000).Back to the Han students of different genders of children and adolescents in detection ofabdominal obesity, abdominal obesity Muslim boys was lower than the Han (ChineseChildren detection rate of return was9.4%,16.1%, respectively), the difference was statistically significant (χ2=64.40p=0.000), back to the Han girls abdominal obesity ratewas not statistically significant (χ2=4.38p=0.223).5) through baseline surveys, screened455obese people,321overweight people, the normal457. Venous blood were collected from1233copies.818copies of the Han, Hui415copies.Three groups of age, gender balance, the difference was not statistically significant (P>0.05).6) different body mass index TG, TC, LDL, GLU, HDL test results showed that TC, TG, LDLobese> overweight> normal group, the differences were statistically significant (P <0.05).7) different ethnic TG, TC, LDL, GLU, HDL test results showed TG Han> Hui, LDL, GLUHan <Hui, the differences were statistically significant (P <0.05).8) Ghrelin gene rs26802, rs42451, rs696217, rs27647genotype and allele frequencies indifferent sites in the body mass index difference was not statistically significant (all P>0.05)9) Ghrelin gene locus genotype rs27647compare the distribution of children in the back to theHan, the difference was statistically significant (P <0.001). Ghrelin gene rs27647loci in Hanchildren of different body mass index next time genotype and allele frequencies werestatistically significant (P <0.05).10) Ghrelin gene rs26802, rs42451, rs696217, rs27647genotype and allele frequencydistribution of the differences were not statistically significant (all P>0.05) in abdominalobesity and abdominal obesity in non.11) HDL, LDL, GLU, TG, TC indicators Ghrelin gene rs26802, rs42451, rs27647loci indifferent genotypes was no significant difference (P>0.05). HDL indicators rs696217locusgenotypes were significantly different (F=6.088P <0.01) differences.12) There Ghrelin gene rs27647locus genotype distribution and allele frequencies betweennormal and abnormal TC group differences statistically significant (=6.72, P=0.03;=5.05, P=0.02), abnormal group C allele frequency is higher than the normal group.Conclusion：1) in Ningxia Hui and Han children and adolescents obese, overweight andabdominal obesity incidence Hui Han children more than children and the difference was statistically significant.2) The incidence of obesity in children and adolescents in the age group of small highincidence, because of the schools, students, parents, education and advocacy to strengthenthe dangers of obesity and how to prevent obesity, such as when the parents for parents toexplain some of the knowledge of obesity, making the school, the students themselves,parents working together to make children more healthy.3) obese children are more likely to abnormal lipid metabolism.4) Ghrelin gene rs26802, rs42451, rs696217, rs27647polymorphism points and Ningxia nocorrelation between childhood obesity.5) genotype C Ghrelin gene locus rs27647/C and C/T and C allele was negativelycorrelated with body mass index. Thus C allele with children obesity, which reduces thelikelihood of the occurrence of obesity carriers.6) Ghrelin gene locus rs696217T/T and T/G genotypes with lipid disorders, whichincreases the risk of suffering from dyslipidemia carriers.7) Ghrelin gene locus rs27647C/C and C/T genotypes with lipid disorders, whichincreases the risk of suffering from dyslipidemia carriers, Ghrelin gene locus rs27647C allelecompared with susceptibility to high cholesterol high. |
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