Research On Bipolar Radio Frequency Ablation System With Cooling For Resistant Hypertension

Hypertension is a worldwide healthy problem. About one third of adults in developedcountries suffer from the hypertension. And the ratio of developing countries is alsoincreasing. At present, there is no effective solution and medicine or drug that can curehypertension, especially resistant hypertension, which is a big trouble for many people. Sowhether we can find a treatment that can fundamentally solve the problem is critical.Medical research shows that, the kidney is very important for adjusting blood pressure.Because that once renal sympathetic nerves were activated, blood vessels would shrink, sothe blood pressure raised. So as long as we can block renal arteries, we will prevent theelevation of blood pressure.This dissertation proposed a method for blocking renal sympathetic nerves which wasinterventional radio frequency ablation with cooling. During ablation, renal sympatheticnerves would be ablated so resistant hypertension could be cured. We named this methodRadio-frequency sympathetic denervation (RSDN).Just now, almost all RSDN devices work with monopolar system. That is to say, thereis only one polar which works during ablation in target tissue. But these devices have manydefects. For example, energy generated by ablation is excessively scattered into nearbyspace, which will damage tissue surrounding target zone. And postoperative complicationswill afflict many people. To avoid these, we proposed a RSDN system that has two workingelectrodes. With3D scanning, this bipolar RSDN system will play a key role in ablation.Besides, we added coolant or cooling medium to us RSDN system. The coolant, whichwas normal saline, would act as a protector to the inner wall of renal artery.In this research, to analyze the feasibility of bipolar RSDN system, ComsolMultiphysics was used to work out finite element analysis. We didn’t fix the values of D1(distance of the two electrodes) and V0(±V0is the electric potential of the two electrodes),but did parametric scanning. Finally, we would find that there were some appropriate valuecouples (a D1and a V0form a value couple) for this RSDN system.And at the same time, to verificating the bipolar RSDN system, we did manyqualitative experiments. Then by comparing the results of the finite element analysis andqualitative experiments, we concluded that the bipolar RSDN system was feasible. Ouranalyses and experiments are valuable, and this dissertation will be a guideline forsubsequent researchers.