Multiple Risk Factors Of Resistant Hypertension In Hospitalized Patients

Objective:To study the relationship between average blood pulse pressure(ABPP), left ventricular mass index(LVMI), modification of diet in renal disease (MDRD), ambulatory arterial stiffness index (AASI) and resistant hypertension respectively, and investigate the predictive validity of the four indexes in resistant hypertension.Methods:387study participants were cruited from Cardiovascular institute of Shan Xi Province, all of them were diagnosed Primary hypertension. There were164resistant hypertensive patients (Select case group is the primary hypertension) and223controllable hypertensive patients(Selection of the control group is successful blood pressure control).We compared the biochemical indexes between the two group, and Logistic regression analysis and ROC curve analysis were analyzed with ABPP, LVMI, MDRD and AASI of them.Results:1This information is displayed in the hypertensive patient in RH accounted for31.32%.2The course of the disease, body mass index (BMI), fasting blood glucose (FBG), triglyceride, cholesterol, ABPP, LVMI, AASI of the case group all higher than those of the control group. The difference was statistically significant.(p<0.05).3A case of group LVMI was significantly higher than that of control group (P<0.001),and a group of eGFR was significantly lower than that of control group (P<0.001).4Multiple logistic regression analysis showed that ABPP(before adjust OR=1.110, after adjust OR=1.111, p<0.001) and LVMI(before adjust OR=2.586, after adjust OR=2.685, p<0.001) are both independent risk factors of resistant hypertension, while MDRD(before adjust OR=0.638, after adjust OR=0.642, p<0.05) is a protective factor. Logistic regression analysis of AASI indicated that no statistical significance(before adjust OR=0.795, after adjust OR=0.757).5ROC curves demonstrate:ABPP, LVMI and AASI do have the predictive validity of uncontrollable blood pressure, which are of statistical significance(p<0.001), and among the three indexes, ABPP lists first(AUC=0.775), then come LVMI(AUG=0.742) and AASI(AUC=0.634).Conclusion:1ABPP and LVMI are risk predictors of uncontrollable blood pressure, the higher the two are, the worse blood pressure could be controlled; MDRD is protective factor, the lower it is, the worse blood pressure could be controlled.2ABPP on blood pressure is difficult to control the degree of the strongest predictors, on hypertension in the diagnosis, treatment, prognosis is better than other index, ABPM because of convenient operation, easy to obtain, should become gradually on the blood pressure of comprehensive inspection method.