The Correlation Studies Between HBV-DNA And Common Clinical Metabolic Indexes Of Blood Glucose In Chronic Hepatitis B Patients

Objective:To study the relationship between HBV-DNA and common clinical metabolic indexes of blood glucose in chronic hepatitis B patients.Methods:128cases of patients were selected from new onset diabetes patients with a history of chronic hepatitis B in5years diagnosed by Endocrine Dept.in the Fifth Affiliated Hospital of Xinjiang Medical University from September2011to October2013as the study objects, ridge regression was made to study the correlation of HBV-DNA and common clinical metabolic indexes of blood glucose.Results:After excluded the effect of confounders, HBV-DNA was positively correlated with the levels of plasma glucose(r=0.297, P<0.001; r=0.156, P<0.001; r=0.656, P<0.001; r=0.432, P<0.001; r=0.649, P<0.001)、 plasma insulin (r=0.305, P<0.001; r=0.476, P<0.001; r=0.395, P<0.001; r=0.386, P<0.001; r=0.561, P<0.001)、plasma C-Peptide (r=0.251, P<0.001; r=0.229, P<0.001; r=0.254, P<0.001; r=0.075, P<0.001; r=0.252, P=0.010)、HIRI (r=0.187, P<0.001) and HBCI (r=0.517, P<0.001), and negatively correlated with ISI (r=-0.159, P<0.001), IAI (r=-0.140, P<0.001).Conclusion:Blood glucose levels would be increased by the growth of HBV-DNA,massive insulin would be secreted by the stimulated pancreatic beta cells, insulin resistance and the insulin sensitivity would be exacerbated,the physiological effect of insulin would be affected,glucose metabolic disorders would be caused or exacerbated.