Relationship Between The Virus-Encoded Chemokine VMIP-Ⅰ、-Ⅱ And Kaposi’s Sarcoma

Objective:To study the Human Herpes virus8(Human Herpes virus-8, HHV-8) virus-Encoded Chemokine vMIP-Ⅰ、-Ⅱ in the Xinjiang Kaposi sarcoma (Kaposi’s sarcoma, KS) patients tissue, blood, saliva and urine. Methods:8cases of Xinjiang Kaposi sarcoma patients’ age of30-78were provided by First Affiliated Hospital of Xinjiang Medical University, which strictly followed the ethical principles and informed consent was written by their families and themselves. Collect their tissue, blood, saliva and urine samples and frozen in-80℃. Genomic DNA was extracted from8frozen tissue, blood, saliva and urine samples of Xinjiang Kaposi sarcoma. Testing vMIP-Ⅰ、-Ⅱ in8cases of Xinjiang Kaposi sarcoma patients’ tissue, blood, saliva and urine using ordinary PCR method, then distinguish by sequencing. Results:vMIP-Ⅰ and vMIP-Ⅱ were detected in All of8tissue samples but Can’t be detected in any saliva and blood samples.Conclusion:HHV-8virus exist in all specimen of Xinjiang typical KS patients’ tissue, blood, urine and saliva, their may be the infection and transmission routes of HHV-8.There are vMIP-Ⅰ and vMIP-Ⅱ in tissue of classic Kaposi sarcoma from XinJiang, they may be associated with the cause of Kaposi sarcoma.