Clinical Observations Of Salviae Miltionrrhizae And Ligustrazine Hydrochloride Injection Solution In Treatment Of Vertebrobasilar Artery Insufficiency After Cerebral Infaretion

Objective:The purpose of this study is to observe the clinical effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection solution in treatment of vertebrobasilar insufficiency after cerebral infarction, and evaluate the safety of clinical application.Methods:The120patients were randomly divided into treatment group and control group, each group had60patients. These patients were insufficient of cerebral infarction blood supply of vertebral basilar artery system, who were treated from2012June to2013July in the neurology wards of Xuzhou City Hospital of Traditional Chinese Medicine. The treatment group were given Injection intravenous drip of Salviae Miltiorrhizae and Ligustrazine Hydrochloride, while the control group were given Shuxuetong Injection intravenous drip. The two groups were given continuous intravenous infusion for two weeks, and the treatment result was observed Patients of the two groups showed no significant difference (P>0.05) in gender, age, course of disease, underlying disease, thus they are comparable. The symptoms and signs were observed before and after treatment. The TCM syndrome integral and the total efficiency were calculated and statistically analyzed, and the effect was compared. The effects of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on patients with TC, TG, HDL-C, LDL-C, blood rheology, transcranial Doppler examinations and clinical symptoms were observed and made analysis.All the data were analyzed with SPSS15.0statistical software processing, the measurement data to x±s, and analyzed using t test; the counting data with χ2test; the grade data with Ridit analysis. All statistical tests, P<0.05or P<0.01had statistical significance.Result:1.The comparison of TCM syndrome improvement is:after treatment, the total effective rate of the patients in the treatment group was96.67%, significantly higher than those in the control group whose total effective rate was81.67%, statistically significant difference (P<0.05).The result shows that the total efficiency and recovery of the treatment group were higher than those of the control group.2.The comparison of TCM syndrome integral is:after the treatment, TCM syndromes in patients of the two groups were significantly lower than those before treatment, statistically significant (P<0.05).The TCM syndrome integrals in patients of the two groups were compared respectively:before the treatment, the two groups had no significant difference (P>0.05);after the treatment, the integrals of treatment group were lower than those of the control group, statistical significance (P<0.05).The experimental results show that:after treatment the TCM syndrome integral of the two groups patients were significantly lower, but the treatment group was better than the control group.3.The comparison of serum lipid improvement is:After treatment, to the patients both in the treatment group and in the control group, blood TC, TG, LDL-C were reduced, HDL-C was elevated, significantly different from before treatment (P<0.05), but the result of the treatment group is better than that of the control group.4.The comparison of Hemorheology value is:after treatment, the blood flow of the patients in the treatment group decreased, significantly different from before treatment (P<0.05), but no significant difference from the condition of the control group after treatment (P>0.05).5.The comparison of transcranial Doppler is:after treatment, the blood flow velocity of the treatment group and the control group, were significantly better than before treatment, statistically significant difference (P<0.05); The comparison of blood flow velocity in two groups:before the treatment, the two groups had no significant difference (P>0.05); after the treatment improvement of the treatment group is significantly higher than that of the control group, statistically significant difference (P<0.05).The results suggest that after treatment, the blood flow velocity of the patients of two groups is improved obviously, but the treatment group is better than the control group.Conclusion:Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection has obvious effect in treatment of cerebral infarction in vertebral basilar artery insufficiency, with low drug side effects, high safety,affordably price, wide useness in clinical worth.