Comparison Of Prognostic Value Of Red Cell Distribution Width And NT-probnp For Short-term Clinical Outcomes In Acute Heart Failure Patients

Background: Comparison of the prognostic value of red cell distributionwidth (RDW) and N-terminal pro B-type natriuretic peptide (NT-proBNP)for short-term clinical outcomes in acute heart failure (AHF) patients hasnot been fully investigated.Method: A total of128patients with AHF were enrolled and followed for3months. Primary endpoints were cardiovascular(CV) events, defined ascardiac death and/or readmission for HF. Baseline RDW and NT-proBNPwere measured at admission.Result: The30-day and90-day CV event rates were16.4%and35.9%,respectively. NT-proBNP was higher in people with cardiovascular eventsat both time points, while RDW was signifi cantly higher only at the90-day time point. The area under the ROC curve of RDW (area under theROC curve=0.695) for the prediction of CV events was higher than thatof NT-proBNP (area under the ROC curve=0.610) at the90-day time point, but lower at the30-day time point. Cox hazard analysis revealedRDW and NT-proBNP were independent predictive factors of a90-dayCV event (RDW, hazard ratio,4.610,95%confidence interval1.935-10.981, P=0.001; NT-proBNP, hazard ratio,3.661,95%confidenceinterval1.125-11.907, P=0.031). Kaplan-Meier survival analysis revealedthat patients with an RDW level>14.5%and NT-proBNP>1471.5pg/mLwere at highest risk for a CV event (P <0.001).Conclusion: RDW and NT-proBNP are strong independent predictors of90-day cardiovascular events in patients hospitalized with AHF. RDW canadd prognostic value to NT-proBNP for predicting early cardiovascularevents.