Ezrin Expression And Its Clinicopathological Significance In Colorectal Cancer: A Meta Analysis

Objective: To investigate the expression and clinicopathologicalsignificance of Ezrin protein in colorectal cancer by Meta-analysis.Methods: Published studies were searched in database in both Englishand Chinese to meet the requirements. Eligible studies which involvedEzrin expression and its clinicopathological significance in colorectalcancer were included. Meta analysis of enrolled studies was performed byRevman5.0software after quality evaluation and the relevant dataextracted.Results: Totally14case-control studies were selected for this Metaanalysis, including1383colorectal caner cases and298normal controls.Results of Meta analysis showed that:①There were significant differencesin positive rate of Ezrin expression between colorectal cancer tissues andnormal tissues(OR=15.72,95%CI=10.56-23.41, P<0.000);②Ezrinexpression were associated with lymph node metastasis (OR=2.96,95%CI=1.69-5.19, P=0.000), Duke classification (OR=0.17,95%CI=0.08-0.37, P<0.000), infiltration depth (OR=0.56,95% CI=0.36-0.85, P=0.007), histological subtype (OR=0.37,95%CI=0.19-0.69, P=0.002), but not associated with sex (OR=1.19,95％CI=0.89-1.58, P=0.24), age (OR=1.15,95%CI=0.69-1.91, P=0.60), tumorlength (OR=1.07,95％CI=0.66-1.73, P=0.79).Conclusions: Expression of Ezrin in colorectal cancer is high. Highexpression of Ezrin may play an crucial role in the process of colorectalcancer development.