| Objective：To investigate the association between two miRNApolymorphisms (miR-499and miR-149) and gastrointestinal (GI) cancerrisk.Methods：We conducted a search of case-control studies in PubMed,Wiley Online Library,Web of Science and the CNKI database. We usedCochrane Review Manager Version5.1and Stata/SE software12.0toanalyze the data from each study.Results：Eleven rs3746444studies and six rs2292832studies wereincluded in our meta-analysis. The only obvious association between themiR-499polymorphism and colorectal cancer susceptibility was found inthe homozygote comparison (GG vs. AA: OR=1.66,95%CI:1.02–2.70,Ph=0.10, P=0.04). No signifcant association was found in the subgroupanalysis for ethnicity and risk of hepatocellular and gastric cancer. Amarginally elevated GI cancer risk was discovered in the recessive modelfor miR-149(TT vs. TC+CC: OR=1.15,95%CI:1.03–1.30, Ph=0.68, P =0.02). Stratifying the results by ethnicity revealed a slight associationbetween the recessive model and the Asian population (TT vs. TC+CC: OR=1.14,95%CI:1.01–1.29, Ph=0.79, P=0.03).Conclusion：The present meta-analysis indicates that miR-499may beassociated with the risk to colorectal cancer. MiR-149may confer amarginally increased risk of susceptibility to gastrointestinal cancer,especially for Asians. |
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