| Objective: To investigate the association between microRNA-146a (the following abbreviated as miR-146a) polymorphism and the risk of gastrointestinal tumors.Methods: A meta analysis of reported data (from28July2010to June2,2013) was conducted that we obtained twenty-six research literature about the association between miR-146a polymorphism and gastrointestinal tumors risk and11met the requirements in accordance with the opt-in and exclusion criteria were selected. OR values and95%confidence interval (95%CI) were used to assess this association.Results:7,038cancer patients and8,660healthy patients as controls in all. And we found that miR-146a (rs2910164) could significantly increase the risk of gastrointestinal tumors, the results of stratified analysis as below:the alleles G/C (OR=1.08,95%CI:1.03-1.13), the dominant genetic model GC+GG/CC (OR=1.11,95%CI:1.03-1.19), the recessive genetic model GG/CC+GC (OR=1.11,95%CI:1.03-1.20), the homozygote GG/CC (OR=1.16,95%CI:1.05-1.27) and the heterozygous CG/CC (OR=1.09,95%CI:1.01-1.18).What’s more, colorectal cancer and gastric cancer stratified analysis was found to be significantly increased prevalence of colorectal cancer risk, but gastric cancer was not significant.Conclusion:According to the meta-analysis, we found that miR-146a polymorphism (rs2910164) was positively correlated to the risk of gastrointestinal tumors especially for colorectal cancer, but not so significant for gastric cancer. |
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