Combined585nm Pulsed-dye And1064nm Nd:YAG Lasers For The Treatment Of Infantile Hemangiomas

Objective:The objective of this study was to determine the clinical effect, treatment sessions and adverse effects of repeated treatment with a combined585nm pulsed dye laser (PDL) and1,064nm Neodymium Yttrium Aluminum Garnet (Nd:YAG) laser on hemangiomas.Methods:Retrospective review of superficial and complicated IHs received combined PDL and Nd:YAG at treatments2-6week intervals during four years. Grouping infants that meet the filter criteria by its gender, age, lesion characteristics and treatment methods. Evaluation is carried out one month after the complete clearance or six treatment sessions by comparing pre-and post-treatment photographs of skin lesions, according to the evaluation criteria will be classified as complete clearance, near-complete clearance, effective and ineffective.Use SASS19.0software for statistical analysis.Results:Approximately most of all tumors showed a complete or near-complete response to six combined PDL and Nd:YAG treatments (n=324/357,90.75%).When stratified by type,97.4%of superficial tumors (n=150/154) showed complete or near-complete response, while85.71%of complicated tumors (n=174/203) showed complete or near-complete response. For complicated IHs, treated concurrently with propranolol and PDL and Nd:YAG achieved near-complete clearance (75/76) more often than IHs treated with concurrently with local lesions glucocorticoids injections and PDL and Nd:YAG(55/65) or treated with PDL and Nd:YAG alone (41/58) and achieved near-complete clearance after fewer treatment sessions of PDL and Nd:YAG (mean7treatment sessions for concurrent propranolol and PDL and Nd:YAG vs10treatment sessions for PDL and Nd:YAG;p<.001). Based on the results, no significant adverse reactions, only a few left scars(8/357,2.24%). Of noted, all the results located in the scalp express an obvious problem of hair growth restriction. Conclusion:Combined PDL and Nd:YAG laser is an effective and safety means of inhibition of tumor growth and reducing tumor burden in infants with hemangiomas and may be a promising, emerging alternative therapy. Factors influencing treatment response includes the age and thickness and type of skin lesions. Early Intervention and combination therapy of choice for improve outcomes are very necessary. Hair growth restriction may partially blame for laser treatment. Total24figures,13tables,38references.