The Clinical Study Of Qushi Shengfa Decoction On The Treatment Of Female Pattern Hair Loss On Damp Heat Syndrome

Background:Nowadays, the morbidity of Female Pattern Hair Loss (FPHL) is increasing. The age of onset was younger than before. The Patients want the most effective treatment of FPHL. Considering the safety problem, the traditional Chinese medicine (TCM) is one of the potential research area. However, there were few clinical researches on FPHL in TCM. Most of them focused on the therapy of reinforcing liver and kidney(补益肝肾)and reinforcing qi and xue(益气养血).There were lack of studies on damp-heat syndrome(湿热证)which is a common syndrome in FPHL patients.Purposes:Observe the treatment effect of Qushi Shengfa Decoction(祛湿生发汤,QSSFT, treatment group) and Qufeng Huanji Bolus (祛风换肌丸,QFHJW, control group) on FPHL patients with damp-heat syndrome. Observe the effect of peripilar sign (PPS) on the FPHL patients.Methods:Collect80cases of FPHL patients with damp heat syndrome from the JiangSu Province TCM Hospital. Randomly Separate40patients in treatment group and control group respectively. After12weeks treatments, compare the observation under dermatoscope, the hairs growth rate on parietal region and the clinical marks (the level of itching, oiliness, dandruff, hair1Results:5cases dropout. The hair growth rates were10.12%和4.28%in treatment group and control group respectively. The mean of hair density in treatment group significantly increased from139.96±22.67(amount/cm2) to153.08±21.918after12weeks treatment (P<0.01) and the mean in control group significantly increased from141.32±18.93to147.30±22.67(P<0.01). There were significantly difference between2groups(P<0.05). Compared the syndromes change, the total clinical effect rates were89.47%and81.08%, without statistical significance. Further, there was significantly different in the distribution of clinical effect between2groups because the sum%of excellence level and recure level in treatment group (44.7%) was higher than the sum in control group (10.8%)(P<0.01). Compared the5clinical marks difference between2groups, the effects in the level of dandruff and oiliness in treatment group (2.48±1.39and3.18±1.59respectively) were significantly higher than the differences in control group (1.35±0.80和1.95±1.20respectively)(both P<0.01). The others(the level of hair loss, newborn hair and itching) were not statistically significant. However, the difference of itching level between the4weeks treatment and before treatment in control group (2.50±1.18) was significantly higher than treatment group(1.52±1.50)(P<0.01).There were50patients with positive PPS (PPS+ve). After the12weeks treatment, the mean of hairs increased19.67±9.20in PPS-ve treatment group(19cases),6.59±10.41in PPS+ve treatment group(19cases),11.73±13.74in PPS-ve control group(16cases) and1.59±9.85in PPS+ve control group(21cases). By the variance analysis, the results showed the mean of hair growth were depended on the treatment methods and the presence of PPS(P<0.05and P<0.001respecitively). The distribution of the clinical effect level(临床疗效评级) in control group was significantly affectd by the presence of PPS(P<0.05), but no statistically significant effect on the cotnrol group.Conclusions:The hair growth rate in the treatment of FPHL by Qushi Shengfa Decoction (treatment group) was higher9%than the treatment by Qufeng Huanji Bolus(control group)(P <0.05). Focusing on the clinical effect on relieving symptoms, Qushi Shengfa decoction group was better than Qufeng Huanji Bolus group(P<0.01) because the better effect of Qushi Shengfa decoction group on reducing oiliness level and dandruff level(P<0.01and P<0.001respectively). However, the effect of Qufeng Huanji Bolus on relieving itching after the4weeks treatment was better than Qushi Shengfa Decoction. The results also showed the presence of PPS reduced the hair growth rate significantly in2groups (Treatment group’s P<0.05; control group’s P<0.001). The results showed that the diagnose of PPS was useful to calculate the effect of treatment in the prognosis of the FPHL patients. Clinically, the Qushi Shengfa Decoction is suggested if the FPHL patients with dandruff and oiliness as main complains. The Qufeng Huanji Bolus is suggested if the FPHL patients wtih serious itching as main complain. On the other hand, the dermatoscope examination is suggested as the clinic routine in FPHL.