Effects Of Alcohol Intake For Women’s Ovarian Reserve And Plasma Prolacin

Objective:To investigate the adverse effect of alcohol on menses, ovarian size and number of antral follicles, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL) and testosterone (T) levels in childbearing women, and analyze the relativity between the amount of alcohol and menses, ovarian size, number of antral follicles, and serum sex hormone levels. To further investigate the mechanism of the alcohol effects on the hypothalamus-pituitary-ovary axis, Study effects of alcohol intake on ovarian reserve and plasma prolacin in women, further refining the etiology of ovarian reserve decreases, in order to provide preventive measure on premature ovarian failure and healthy birthing and childbearing.Methods:1.30KTV waitress have had moderate alcohol consumption for over3years in the research group, and select30KTV not drink waitress in the control group.2.vein blood was collected from all of the subjects in the menstrual cycle day two to day five. At the same time using transvaginal B-ultrasound or rectum B-ultrasound to examine uterine size, ovarian volume, bilateral ovarian antral follicle count.3. Serum LH, FSH, E2, PRL and T levels were measured using electrochemical luminescence. To analyze the relativity between the amount of alcohol and menses, basal sex hormone levels, ovarian size, number of antral follicles.Results:1.In the research group, a total of15subjects have abnormal menstrual flow, in contrast, in the control group, only7subjects have abnormal menstrual flow. The unusual ratio in research group was substantially higher than the control group (P=0.032), P<0.05. for the abnormal menstrual cycles,9cases in research group,6cases in control group no significant difference between the two groups.(P=0.375), P>0.05。2. Significantly higher level of serum FSH was observed in research group (7.87±1.70mIU/ml VS5.61±1.48mIU/ml)(p=0.000), P<0.01.Significantly higher level of serum E2was observed in research group (255.00±30.63pmol/l VS215.98±47.06pmol/l)(p=0.000), P<0.01. Significantly higher level of serum FSH/LH was observed in research group (1.55±0.41VS1.23±0.40mIU/ml)(p=0.003), P<0.05. Significantly higher level of serum PRL was observed in research group (377.44±90.49uIU/ml VS289.45±67.74uIU/ml)(p=0.000), P<0.01.In contrast, no significant differences in serum LH(5.20±0.99mIU/ml VS4.95±1.84mIU/ml), and TST (0.28±0.11ng/ml VS0.31±0.22ng/ml) levels were observed between two groups.3. The results from transviginal B-ultrasound showed that the research group had significantly decreased between the ovarian volume (4.26±0.51ml VS5.41±0.40ml)(p=0.000), P<0.01. and the number of ovarian antral follicles (8.63±1.69VS12.93±1.86)(p=0.000), P<0.05.compared to the control group.4.The amount of alcohol consumption was positively correlated with serum FSH(r=0.676, p=0.000), E2(r=0.511, p=0.000), PRL(r=0.447, p=0.001)andFSH/LH(r=0.437, p=0.000) levels, P<0.01. and negatively correlated with the number of antral follicles (r=-0.860, p=0.000) and ovarian volume (r=-0.820, p=0.000), P<0.01.Conclusion:1. Alcohol intake can decrease in the number of antral follicles and ovarian volume reduction, and cause elevated serum E2、FSH, and lead to diminishe ovarian reserve and menstrual disorders. 2. Alcohol intake can cause elevated serum prolactin.