The Main Allergen Analysis And Intervention Treatment Effect Observation Among405Year-old Children With Asthma

Objective:To explore the distribution of allergens of3-13year-old children with asthma, And to evaluate the intervention treatment effect of childhood asthma.Methods:405serum specimens were collected from children of3to13years old children with asthma. Serum specimens were tested for allergens by Western blot. In the study, we assessed the treatment effect after intervention therapy by the days of asthma symptoms per year. This study uses spss16.0statistical analysis, descriptive statistic method is applied to analyze the distribution of specific allergen, genetic family history, personal history of allergies, compared before and after intervention. Comparison of rates or proportions is peformed by chi-square test or Fisher’s exact probability method, the data not meet the normal distribution is analyzed by rank sum test.Results:Among the deteced children with asthma, the TIgE detected rate was98.5%, the SIgE detected rate was89.4%. In inhalant allergens, the positive rates of house dust mite allergen, dust mite and house dust were44.0%,43.7%and33.8%, respectively. In food allergens, the positive rates of milk and egg were28.9%and25.4%, respectively. The total positive rate of food allergens of childhood asthma aged≤6years was53.2%, while the total positive rate of food allergens of childhood asthma aged>6years was40.4%. The milk positive rate of childhood asthma aged≤6years was33.3%, that of childhood asthma aged>6years was23.5%. The detected rate was significant difference in the age distribution (X2=6.505, P=0.011)(x2=4.724, P=0.030). Inhalant allergens and food allergens are more positive in children aged≤6years, and inhalant allergens and food allergens are more negative in children aged>6years. The difference is statistically significant (Χ2=12.562, P=0.006). The positive rates of inhalant allergens and food allergens between different gender children are not statistically significant. In addition,13.6percent (55/405) of patients have the history of parental asthma,51.6percent (209/405) of patients have the history of eczema,30.9percent (125/405) of patients have suffers from allergic rhinitis,37.3percent (151/405) of patients have the history of urticaria. There are no statistic significance on history of parental asthma, history of eczema, allergic rhinitis, history of urticaria in patients with different gender and different age group. Comparison of the effect of the intervention,The days of asthma symptom per year after interventions are less than that of before interventions (Z=-17.458, P=0.000). The reduced days of asthma syptoms per year before and after interventions are larger in children aged≤6years, the difference is statistically significant (Z=-2.225, P=0.026). Genetic family history, personal history of allergies are asthmatic children has no effect on intervention effect. No significant differences in different genetic family history, personal history of allergies in children with asthma.Conclusions:Among the deteced children with asthma, the TIgE detected rate and the SIgE detected rate is a high detection rate. Among them, the inhalant allergens of childhood asthma are mainly house dust mite, dust mite and house dust, and the main food allergens are milk, egg. Compared with the children aged>6years, the food allergens are more commom in children aged≤6years. Among asthma children, after allergen avoidance. The clinical symptom can be controled or relieved through intervention. The treatment effect of children aged>6years is better than that of children aged≤6years.