Changes Of D Dimer And FIB In Liver Cirrhosis Associated With Chronic HBV Infection And The Effect Observation After Stem Cells Treatment

ObjectiveTo investigate serum D-dimer (D-D) and plasma fibrinogen (FIB) changes and their clinical significance in patients with decompensated liver cirrhosis associated with chronic HBV infection; to research the early efficacy of umbilical cord mesenchymal stem cells (UCMSC) treatment in patients with decompensated liver cirrhosis associated with chronic HBV infection.MethodsPart I:73patients with liver cirrhosis associated with chronic HBV infection (class A27cases, class B26cases, class C20cases) were the object of the study.24healthy persons, who were in the same period were the comparisons. Serum D-D and plasma FIB levels were tested. To compare the D-D and FIB between the cirrhosis group and the comparisons.To compare D-D and FIB in class A,B and C respectively, in order to evaluate their diagnostic value in the degree of liver function damage in patients with decompensated liver cirrhosis associated with chronic HBV infection.Part II:45patients were included in the study, all the patients have received basic medication.19patients, who received UCMSC treatment were considered as the cures; other26patients were considered as the comparisons. To compare TBiL’s difference, Albumin’s difference and PTA’s difference between the two groups in1,2,4,8,12weeks, in order to observe the early effect. To compare the occurrent differerces of complication between the two groups through the survival curve.Results1. Serum D-D and plasma FIB levels had significant difference between the cirrhosis group and the comparisons. Serum D-D levels had significant difference in class A, Band C. Plasma FIB showed no significant difference between class A and B, but it showed significant difference in class C compared with class A and B.2.The levels of Alb and PTA were both higher than the baseline’s. The level of TBiL was lower than the baseline’s. The three indexs’ differences were better in the cures than in the controls. In12weeks, the proportion of class C,which in the cures was lower than that in the controls. The Cum survival clewd that the cumulative incidence of masculine affairs (such as ascites, hepatic encephalopathy, and so on), which in the cures was lower than that in the comparisons (P=0.043).Conclusions1. The levels of serum D-D and plasma FIB are closely related to the degree of liver damage. Their detections contribute to the assessment of the severity of iver cirrhosis associated with chronic HBV infection and treatment guidance.2. UCMSC is effective for decompensated liver cirrhosis associated with chronic HBV infection patients, but its long-term efficacy needs a further study.