Association Between Mutant Allele Of CYP19, COMT And Endometriosis And Adenomyosis

Objective:To investigate the association between polymorphism of CYP19240A/G, COMT1947G/A and endometriosis (EMs) and adenomyosis (AM).Methods:From September2011to March2012, thirty cases of EMs and fifty cases of AM were recruited into study. Meanwhile, thirty-eight cases (use PCR-RFLP technology) and forty cases (use HRM technology) without EMs and AM were included into control group. The bloods were collected from all of them in the morning after operation. The correlation between the multibus of two genes about EMs and AM was evaluated by PCR-restriction fragment length polymorphism (PCR-RFLP) and high resolution melting (HRM).The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Affiliated Hospital of Binzhou Medical College. Informed consent was obtained from all participates’parents.Results:There was a significant difference of the alleles and genotype of CYP19240A/G between EMs group, AM group and control group (p<0.05). The mutant allele of G made relative risk suffered from EMs and AM got the raise. The relative risk suffered from EMs and AM of AG and GG genotype got the raise to GG genotype, respectively. There was no significant difference of the alleles and genotype of COMT1947G/A between EMs group, AM group and control group (p>0.05). There was no significance between the genotype that caught A (GA+AA) and GG genotype (p>0.05). There was no correlation between GA and AA genotype and the risk suffered from EMs and AM.Conclusions:The mutant allele of CYP19240A/G increased the risk suffered from EMs and AM. The mutant allele of COMT1947A/G had no relationship with the risk of EMs and AM.