IFN-γ, IL-4and IL-17in The Associated With Asthma Nasal Polyp And Endoscopic Sinus Surgery In The Vesicles Express Research

Background and objectiveNasal polyps is occurred in the middle nasal meatus edema inflammatory mucosal prolapse formation, is the result of various causes of rhinosinusal mucosa chronic inflammation. The recently proposed is closely related to the occurrence of Th1/Th2/Thl7imbalance and nasal polyps, cytokines in the occurrence and development process involves a variety of incidence of resident cells and effector cells and the, Their interaction and the formation of chronic airway inflammation, including related factor IFN-γ, IL-4and IL-17etc, The study of IFN-γ, IL-4and IL-17in patients with asthma and nasal polyps after endoscopic sinus surgery vesicle tissues. Study on Th L/Th2/Thl7imbalance theory significance correlation between the occurrence of bubbles in nasal polyp and cyst, provides theoretical basis for improving the clinical curative effect and prognosisMethodsBy immunohistochemistry SP method was used to detect IFN-γ, IL-4and IL-17in nasal polyps and distribution associated with asthma, nasal polyp and nasal endoscopic surgery in vesicles expression, For each factor bubble expression relationship with the correlation and the correlation of the disease in nasal polyp and cyst.Result1.Under light microscope, nasal polyp epithelial hyperplasia thickening, visible squamous metaplasia, The subepithelial stroma edema, interstitial loose connective tissue, which a small amount of dilated microvessels and cystically dilated glands, interstitial in Eos, neutrophil infiltration, Otherwise there are lymphocytes and plasma cells.Vesicle tissues were pseudostratified ciliated columnar epithelium, lamina propria edema, epithelial layer of eosinophil infiltration with a few neutrophils and plasma cells, epithelial layer visible small blood vessels and glands. 2. IFN-γ, IL-4and IL-17positive cells could be seen more in nasal polyps, Characteristic: The positive cells were also cluster distribution, More concentrated in the peripheral epithelial and glandular blood vessels in the stroma, scattered, Visible in lymphocytes, eosinophils, epithelial cells, vascular endothelial cells expressed. Inflammatory cell membrane vesicle tissue the positive cells of IL-4and IL-17Y IFN-, located in the submucosal and interstitial and cytoplasm, expression of EOS aggregation site is strong. IFN-γ, IL-4, IL-17expression in nasal polyp group and asthma, nasal polyps and vesicle tissues was significantly correlated (P<0.05) with asthma, nasal polyps and vesicles positive expression rate of higher (all OR layered after>OR layered before)ConclusionAnalysis of correlation showed that IFN-Y, IL-4, IL-17in patients with asthma with or without nasal polyps group and vesicle tissues expression was significantly correlated with, With asthma and nasal polyps and vesicles positive expression rate of higher, Th1/Th2/Thl7imbalance theory in asthma with nasal polyposis, nasal polyp and nasal endoscopic operation after vesicle has important significance, And in order to provide some theoretical reference for the treatment of nasal endoscopic operation after.