Relationship Between Serum Triglyceride/High-density And Its Clinical Significance In Type2Diabetic Retinopathy

Background and PurposeDiabetes mellitus (diabetes mellitus,DM) is due to the insulin secretory defect, or (and) insulin disorders caused by metabolic disorders of blood glucose levels.The prevalence of diabetes in the world show a growing trend. World Health Organization statistics data show that Diabetes prevalence of approximately150million people around the world, predicted that by2025, this data will be increased1time. Diabetes has become a serious threat to human health from chronic non-communicable diseases. According to the latest epidemiological data, the prevalence of diabetes in China had reached9.7%, reaching a total of92.4million. Along with development of Chinese economic, People’s material improving of living standards, changing in eating habits and living structures, The prevalence of diabetes will rise year by year. There is also a problem that we can not be overlooked in diabetic complications. Long chronic high blood sugar can cause multiple system organ failure and disorders, such as macroangiopathy of diabetes mellitus (atherosclerosis), diabetic nerve disease, diabetic microangiopathy (diabetic retinopathy, diabetic nephropathy)Diabetic retinopathy (DR) is one of the most common microvascular complication of diabetes.Researchers found that patients with type1diabetes mellitus appear about95%DR. Type2diabetes appears about60%DR. First diagnosed with type2diabetes mellitus patients, More than21%have been DR. And diabetic retinopathy progresses with the time. Although many diabetic retinopathy treatment, but it is still one of the leading cause of acquired blindness.Diabetic dyslipidemia refers to the blood levels of total cholesterol (CHOL), triglycerides(TG) and low-density lipoprotein (LDL) levels, and high-density lipoprotein (HDL) levels and other blood lipids biochemical changes. Dyslipidemia of lipid is metabolism disorder, and a metabolic disease, But its damage to health are manifested in the cardiovascular system, which causes of atherosclerosis in coronary heart disease and other diseases. Researchers have confirmed abnormal lipid metabolism has become risk factors for coronary heart disease in patients with type2diabetes. Diabetic retinopathy is diabetic microangiopathy, its study on relationship between lipid metabolism and although there are, but researchers disagree.But on the ratio of retinopathy in type2diabetes mellitus and serum TG/HDL,there is no documentation in this regard in reports research internally. Therefore this study focuses on serum triglyceride and high density lipoprotein (TG/HDL) ratio and the relationship between diabetic retinopathy and its clinical significance.MethodsSelected from November2011to May2012in the Department of Endocrinology,131inpatients with type2diabetes were male and69cases and62females, aged27years old to83years old, on average (54.60±8.79) years old.131patients with Type2diabetes mellitus were divided into three groups according to their fundus condition. There were28patients with no diabetic retinopathy (NDR),85with nonproliferative diabetic retinopathy(NPDR),18with proliferative diabetic retinopathy(PDR).All selected patients were measured on admission height (m) and weight (Kg), and calculated body mass index (BMI).Re-admission after three days before getting up in the morning under fasting conditions, using standard mercury sphygmomanometer to measure seat right arm blood pressure recording systolic blood pressure (SBP) and diastolic blood pressure (DBP).Three times average recorded values of blood pressure measurement.Clinical parameters related to the progression of DR,including cholesterol triglycerides(TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein (LDL) and apolipoproteinAI(apoAI), apolipoproteinB100(apoB100); TG/HDL were determined and assessed. SPSS17.0statistical software used for data processing. Results are expressed as mean±standard deviation to represent the different qualitative data were compared between groups using the X2test, qualitative data using one-way ANOVA, a significant difference for the various indicators of its relationship with the DR Logistic regression analysis using binary.ResultsAll collected131patients are28patients with no diabetic retinopathy (NDR,21.37%)),85with nonproliferative diabetic retinopathy(NPDR,64.86%),18with proliferative diabetic retinopathy(PDR,13.74%).Age (years) was46.79±6.92、54.60±6.40and66.78±7.43in NDR,NPDR and PDR group. Difference of age among the three groups are of statistical significance (P=0.000)Course (years) was5.81=±1.69,11.67±1.88and18.24±1.65in NDR,NPDR and PDR group. Difference of course among the three groups are of statistical significance (P=0.000)Systolic blood pressure (mmHg) was136.11±18.49.143.18±18.49and155.56±23.68in NDR,NPDR and PDR group. Difference of systolic blood pressure among the three groups are of statistical significance (P=0.005).High-density lipoprotein cholesterol (mmol/1) was1.29±0.34、1.20±0.28and1.02±0.30in NDR,NPDR and PDR group. Difference of high-density lipoprotein cholesterol among the three groups are of statistical significance (P=0.005).TG/HDL ratio was2.79±1.11,2.85±0.83and4.00±1.72in NDR,NPDR and PDR group. Difference of TG/HDL ratio among the three groups are of statistical significance (P<0.001)Sex, fasting glucose, diastolic blood pressure, glycosylated hemoglobin, body mass index, CHOL, APOPA1, APOB100, LDL, TG difference was not statistically significant in NDR,NPDR and PDR group (P>0.05).Logistic regression analysis showed a positive correlation displayed between TG/HDL ratio and DR (B=1.795, P=0.032), courses and DR B=1.003, P=0.007) ConclusionTG/HDL ratio may be used as an effective indicator for the assessment and treatment of DR.