The Clinical Analysis Of Relevant Risk Factors In Diabetic Retinopathy Of Type2Diabetes Mellitus

BackgroundDiabetes mellitus(DM) has become the global health problem nowadays. Theprevalence of DM increased rapidly in the world,particular in developing countries.According to the latest International Diabetes Federation(IDF) reports,adult Diabetes’population in China has overtaken India and become the number one in the world. Alarge number of studies have showen that diabetes itself is not terrible but is themultiple chronic complications of diabetes. Diabetic retinopathy(DR),as one of the mostcommon and serious diabetic microvascular complications,has become one of the majorblinding disease of labor groups in most countries around the world,brings enormousspirit pressure and economic burden to individuals and society. Therefore,it has becomean important research topic to explore the relevent risk factors of DR and discovertimely and take the effective prevention-control measures.Objectives1.To determine the prevalence of DR and to investigate the relevent factors in DRpatients with type2diabetes mellitus(T2DM),provide a clinical support for earlydiscover, prevention and postponement with DR development,and take further measuresto reduce the mental pressure and economic burden of private and society.2.To fill the field blank of regional status of the prevalence of DR in T2DMhospitalized patients. Provide a reference for the formulation of public health policy ofShenyang. Methods786cases of hospitalized Medicare-patients with T2DM during January1,2013toDecember31,2013in the department of endocrinology in the202th hospital of people’sliberation army were entrolled for taking retrospective analysis. Based on the releventdiagnostic criteria for screening,618cases of clinical data were collected. According tothe Diabetic Retinopathy Internation Standards(2002) and the free mydriatic fundusphotography result,618patients were divided into noraml group (NDR);non-proliferative diabetic retinopathy group(NPDR), includingⅠstage、 Ⅱstage and Ⅲstage; proliferative diabetic retinopathy group(PDR), including Ⅳ stage、Ⅴstage、Ⅵstage. Patient’s gender,age,duration of diabetes, Body Mass Index(BMI), Fasting bloodglucose(FPG),2h Postprandia glucosel(2h PPG), glycosylated hemoglobinA1C（HbA1C）,Total Cholesterol(TC), Triglycerides(TG), Low-density lipoproteins Chole-sterol（LDL-C）,Apo(a), blood pressure(BP),blood uric acid, diabetic nephropathy(DN),diabetic peripheral neuropathy(DPN), coronary heart disease(CHD) were analyzed byspss17.0. Then use regression analysis of logistic with the risk indicator’s.Results1.The gender, BMI, FPG,2hPPG, HbA1C, TC, TG, Apo(a) in different groups didnot show any difference(P＞0.05) by Chi-square test. However,the progression ofdiabetic retinopathy and revelent factors including age,duration of diabetes,LDL-C, highblood pressure, high blood uric acid, DN, DPN, CHD show statistically significant(P＜0.05) in different groups.2.Eight statistically significant factors were took into multifactorial unconditionallogistic regression equation to come to: the most important risk factor in DR is thehistory of sugar disease(OR=2.734,P<0.0001),and the following is DN(OR=2.654,P<0.0001). DPN(OR=2.054,P<0.01),high blood prssure(OR=1.512,P<0.05),LDL-C(OR=1.491, P<0.05) were all risk factors for DR. However the factors of age, high blood uricacid,CHD were not entered into the regression equation.ConclusionsMultiple risk factors affect the occurrence and development of DR. The mostimportant risk factor in DR is the duration of diabetes,other risk factors were involved in the sequence of diabetic nephropathy,diabetic peripheral neuropathy,high bloodpressure, Low-density lipoproteins Cholesterol.