The Research Of COPD Dialectics And Herbs Based On Famous TCM Doctor’s Experience

Objective: Establish a "modern old TCM doctor’s diagnosis COPD literaturedatabase ",analyzing Modern old TCM doctor’s treating experiences and drug lawson chronic obstructive pulmonary disease (referred to as COPD). Provide the basisfor revising the COPD Chinese medical practices and clinical prescriptionmedication.Methods: Using the literature about the modern old TCM doctor’s experience ofdiagnosis and treatment of COPD, which from"Modern lung old TCM doctorDatabase"(1911-2011) and "pulmonary medicine journals Database"(1989-2012years), establishing a "modern old TCM doctor’s diagnosis COPD literature database".Using descriptive analysis, correlation analysis, cluster analysis,and factor analysis,researching literature which is about diagnosis and treatment of COPD in modern oldTCM doctor. Summarize the distribution of COPD pathogenesis, syndrome elementdistribution and composition,common syndrome, prescription compatibility law.Results: The study included33journal articles and85kinds of books, a total of550data. Include283data described in etiology,391data described in pathogenesis,379data described in syndromes,526data described in commonly used prescription,550data described in Chinese medicine treatment.1Pathogenesis distribution:17kinds of COPD etiology, which frequency>10%asfollows: Sputum (51.6%), Xu (43.5%), Han (17.7%), Yin (10.6%);80kinds ofpathogenesis, which frequency>5%as follows: Phlegm blocking in lung (38.6%),Retention of Heat-Phlegm in the Lung (19.5%), deficiency of both qi and yin of lung(12.9%), lung-kidney vacuity (7.9%), deficiency of lung-spleen qi (7.4%),Phlegm-Accumulation Stasis (6.9%), water-cold attacking lung (6.9%), Kidney Qideficiency (6.6%), deficiency of lung yin (6.1%), Deficiency of spleen-yang andkidney-yang (5.1%).2The Combination and distribution of syndrome element: These are17kinds of syndrome element of etiology and6kinds of disease location. Frequency of theetiology>10%, as follows: sputum (60.4%), qi (55.7%), fever (33.2%), Yin(21.5%), Yang (14.8%), cold (14.5%), beverages (12.7%), blood stasis(11.9%); common disease location is lung (88.6%), kidney (33.9%), spleen(23.8%); syndrome element combination in the form of: lung, sputum, fever; lungqi deficiency, blood stasis; spleen, kidney, Yang and drink; lungs, wind, cold; lung,spleen, kidney, qi.3Common syndrome: A total of40syndromes, nine kinds of syndromes frequency≥5%, as follows: phlegm obstructing lung syndrome (32.2%), phlegm Yun-lung(20.9%), lung and kidney qi deficiency syndrome (18.5%), lung Qi Deficiency(13.7%), lung spleen deficiency syndrome (10.0%), cold drink stop lung (7.7%),lung phlegm (7.1%), deficiency syndrome (5.3%), Yang deficiency (5.0%).4Common Prescription: there is526data which have a clear direction of names.Higher frequency of application were: Maxingshigan decoction (12.8%),Xiaoqinglong decoction (9.7%), Erchen decoction (7.9%), Sanziyangqin decoction(5.4%), Shengmaisan (5.4%), Liujunzi decoction (3.9%).5Commonly Chinese medicine: there is550data which is about Chinese medicine, atotal of312listed Chinese medicine. The medicine have a higher frequency asfollows: almond (45.1%), Pinellia (42.9%), Poria (38.7%), Schisandra (37.8%),ephedra (31.9%), Suzi (24.5%), Citrus (24.4%), Atractylodes (22.8%), gypsum(22.7%), Morus alba (20.9%). Frequency>10%of the drug cluster analysis showedthat8groups of drug combinations:①Guizhi, peony,Schisandra, Asarum, Ginger;②Poria, Atractylodes,Pinellia, Citrus;③Radix, Radix, Rehmannia, Chinese yam;④angelica, astragalus,Suzi,Tinglizi;⑤Morus alba, bellflower,skullcap, melon;⑥dangshen, aconite;⑦ephedra, gypsum,almond, licorice;⑧Aster, Coltsfoot.6The pharmaceutical analysis of main syndromes6.1Syndrome of turbid phlegm obstructing lung: The common prescription is Erchendecoction,Sanziyangqin decoction,Liujunzi decoction.6commonly used Chinesemedicine taste, according to the frequency as follows: Almond (57.4%), Poria(54.1%), Pinellia (53.3%), Schisandra (39.3%), Citrus (39.3%), ephedra(32%). Frequency higher than15%of the drug in the factor analysis to extract sevencommon factors. Male Factor1: Mustard Seed, Radish, Suzi. Male Factor2:Pinellia, Citrus, Poria. Male Factor3: Radix, Radix. Male Factor4: ginger, cassiatwig, Ephedra, Asarum, Schisandra, white peony root. Male Factor5: bellflower, loquat, almond. Male Factor6: gypsum. Male Factor7: Atractylodes, Aster.6.2Retention of Heat-Phlegm in the Lung: The commonly prescriptions isMaxinshigan decoction,weijing decoction,Sanziyangqin decoction.6commonly usedChinese medicine taste, according to the frequency as follows: Almond (62.8%),gypsum (58.9%), ephedra (44.9%), bellflower (39.7%), Pinellia (38.5%),Morus alba (35.9%). For frequencies greater than17%of the drug factor analysisextracted five common factors. Male Factor1: Ephedra, almond, gypsum, orange.Male Factor2: Fritillaria, skullcap, bellflower, Morus alba. Male Factor3: Suzi,Tinglizi. Male Factor4: ginger, Breit, Schisandra. Male Factor5: Coltsfoot, Aster.6.3Syndrome of cold fluid-retention suspend in lung: The commonly usedprescriptions is Xiaoqinglong decoction,Zhen Wu Tang decoction,lingguizhugandecoction.11commonly used Chinese medicine taste, according to the frequency asfollows: Schisandra (58.6%), Gui (55.2%), Poria (55.2%), Asarum (51.7%),white peony root (51.7%), ginger (51.7%), pinellia (41.4%), Atractylodes(34.5%), monkshood (34.5%), Suzi (31.0%), ephedra (31.0%). Frequencyhigher than15%of the drug in the factor analysis,6male factor extract. Male Factor1: Schisandra, white peony root, cassia twig, Ephedra, Asarum. Male Factor2:Poria, aconite, ginger. Male Factor3: Aster, Coltsfoot, psoralen. Male Factor4:Breit, ginger, orange peel, Mustard Seed. Male Factor5: Suzi. Male Factor6:Codonopsis, Tinglizi almonds.6.4Phlegm and Blood Stasis Syndrome: The commonly used prescriptions isXuefuzhuyu decoction, Xiaoqinglongtang decoction, Zhen Wu decoction.6commonlyused Chinese medicine taste, according to the frequency as follows: Schisandra(48.1%), Suzi (44.4%), peach (40.7%), TPG (37.0%), Pinellia (37.0%),Astragalus (33.3%). Frequency higher than15%of the drug in the factor analysis,6male factor extract. Male Factor1: angelica, safflower, almond, Pinellia. MaleFactor2: Citrus, TPG, Poria, Radish, Suzi, Aster, Tinglizi. Male Factor3: Radix,Trichosanthes. Male Factor4: root, ephedra, almond. Male Factor5: Fritillaria,Schisandra. Male Factor6: aconite, Gui.6.5Syndrome of insufficiency of lung and kidney qi: The commonly usedprescriptions is Duqi decoction,Shenqi decoction,liujunzi decoction.6commonlyused Chinese medicine taste, according to the frequency as follows: Schisandra(50%), Pinellia (41.4%), Poria (37.1%), Suzi (32.9%), Citrus (32.9%),almonds (30%). Frequency higher than15%of the drug in the factor analysis,5 male factor extract. Male Factor1: Angelica, Pinellia, Citrus, cinnamon, Suzi,Magnolia. Male Factor2: aconite, ginger. Male Factor3: aloes, SchisandraAstragalus, Codonopsis, Poria, dogwood, Rehmannia. Male Factor4: almonds.Male Factor5: Coltsfoot, Aster.6.6Syndrome of deficiency of both qi and yin of lung: The commonly prescription isShengmaisan decoction and Maimendong decoction.6commonly used Chinesemedicine taste, according to the frequency as follows: Almond (65.4%), Radix(48.1%), Radix (40.0%), bellflower (36.5%), Poria (30.7%), Astragalus(30.7%). Frequency higher than15%of the drug in the factor analysis to extractseven common factors. Male Factor1: Radix, Radix, Schisandra, Poria, orange,astragalus. Male Factor2: loquat, almond, Yiyiren, phragmites, Yuzhu, pock-jen.Male Factor3: Digupi, Morus alba, sea pumice, Tinglizi. Male Factor4:bellflower, Peucedanum, ephedra. Male Factor5: skullcap, Melon, Mulberry. MaleFactor6: Coltsfoot, Aster. Male Factor7: mother, pearl, orange peel.6.7Pi-Fei qi-deficiency syndrome: The commonly prescription is Sijunzi decoction.5flavor commonly used Chinese medicine, according to the frequency as follows:Atractylodes (47.4%), Aster (42.1%), Astragalus (39.5%), bellflower (36.8%),Poria (34.2%). Frequency higher than15%of the drug in the factor analysis,6malefactor extract. Male Factor1: wind, Atractylodes, Astragalus. Male Factor2:Angelica, Poria, Radix, bellflower, Citrus aurantium, Aster. Male Factor3: Ephedra,Morus alba, almonds. Male Factor4: peony, peony, Shegan. Male Factor5: Radix,walnuts. Male Factor6: Gallus gallus.6.8kidney-yang deficiency syndrome: The common prescription is ZhenWudecoction.8flavor commonly used Chinese medicine, according to the frequency asfollows: Poria (47.6%), ginger (47.6%), cinnamon (47.6%), ephedra (38.1%),Rehmannia (38.1%), Gecko (33.3%), Schisandra (33.3%), Atractylodes(33.3%). Frequency higher than15%of the drug in the factor analysis to extractseven common factors. Male Factor1: Dodder, Schisandra, Astragalus, Chineseyam. Male Factor2: ginseng, dogwood, ginger. Male Factor3: Eucommia, redpeony, peach, hyssop, Polyporus, peony, Atractylodes, Shichangpu. Male Factor4:Gecko, Rehmannia, cinnamon. Male Factor5: psoralen, Codonopsis, Poria,Ginger. Male Factor6: Alisma, aconite. Male Factor7: Gui, ephedra, Suzi.6.9Yang deficiency syndrome: The commonly used prescriptions is Xiaoqinglongdecoction.11commonly used Chinese medicine taste, according to the frequency as follows: ginger (84.2%), Schisandra (57.9%), monkshood (57.9%), Pinellia(52.6%), Gui (52.6%), ephedra (52.6%), fine Sim (47.4%), white peony root(47.4%), ginger (42.1%), Atractylodes (36.8%), Poria (31.6%). Frequency ofgreater than15%of the drug factor analysis extracted four common factors. MaleFactor1: Ephedra, Gui, Asarum, Schisandra, ginger, white peony root. Male Factor2: aconite, psoralen, Alisma. Male Factor3: Astragalus, Ginger. Male Factor4:Pinellia, Citrus, Poria, Atractylodes.Conclusion:1Major etiology of COPD is sputum, weak, cold, fluids, Phlegmblocking in lung is the main pathogenesis.2The main etiology syndrome element is phlegm, qi, heat.The main disease locationis lung, kidney, spleen.3There are nine common syndrome that phlegm obstructing lung syndrome, phlegmYun-lung, lung and kidney qi deficiency, lung Qi Deficiency, lung spleendeficiency syndrome, cold drink stop lung, lung phlegm, deficiency syndrome, yangdeficiency.4Frequency analysis, factor analysis, cluster analysis methods can be used to studythe law of herbs,commonly used herbs have the effect on Expectorant,Antitussiveantiasthmatic, tonify spleen and lung and kidney, warming the lung to reduce wateryphlegm, resolving phlegm,removing blood stasis.