The Clinical Efficacy By Qingxiao Enema Treatment Of Ulcerative Proctitis And Its Impact On Hypercoagulable State

Objective:1. observe Qingxiao enema treatment of ulcerative proctitis effect on colorectal patients withactive heat type, and to evaluate its safety.2. Research Qingxiao enema ulcerative proctitis in patients with serum D-2dimer (D-D),platelet count (PLT), and mean platelet volume (MPV) effects, from improving aspects ofhypercoagulable states discussed Qingxiao enema agents may play a role in the mechanism.Methods:1. Patients with ulcerative proctitis randomized controlled clinical trial methodology, andwill meet the inclusion criteria ulcerative proctitis patients enrolled40patients in thetreatment group and a control group of20cases. Two groups of patients in terms of gender,age, disease duration, disease classification and treatment of pre-clinical symptoms and signs,such as colonoscopy mucosa were not statistically different, comparable (P>0.05).2. treatment group was given an enema40ml Qingxiao retention enema, the control groupreceived rehabilitation new liquid40ml retention enema,2times a day, a course of a month.The total effect was observed before and after treatment in both groups, the main symptomsand signs, such as endoscopic mucosal changes in the colon, as well as before and aftertreatment serum D-D, PLT and MPV levels and determine whether the occurrence of adversereactions.Results:1. A treatment group and the control group, the total effective rate was90.00%,70.00%,indicating that in general to evaluate the clinical efficacy of the treatment group wassignificantly higher (P <0.05).2. groups of patients before and after treatment than before treatment in clinical symptomsand signs improved mucosal like colonoscopy showed significant improvement (P <0.05), inwhich the treatment group improved more significantly in the treatment group than thecontrol group (P <0.05). 3. Reduce serum D-dimer levels and platelet counts in patients treated group, increased meanplatelet volume levels were significantly higher than the control group (P <0.05), the twogroups can improve the patient’s hypercoagulable states, the treatment of the disease iseffective.4. treatment groups with clear consumer enema enema after his abdominal distension anddiscomfort were significantly lower than the control group, the adverse reactions were2cases (10%) and8patients (40%), two adverse reactions there are significant differencesin the rate (P <0.05).Conclusion:1. Qingxiao enema with heat and dampness, promoting blood circulation, reduce swellingand pain of the power, can significantly improve the clinical symptoms, signs andmicroscopic signs of heat treatment of active ulcerative proctitis colorectal validprescription, no significant adverse reactions.2. patients with ulcerative proctitis presence of hypercoagulable states, Qingxiao enemaretention enema to treat ulcerative proctitis significant effect. By heat and dampness,promoting blood circulation to improve blood hypercoagulable state may be onemechanism to play a clinical role.