| ObjectiveThrough a prospective study to observe the clinical curative effect and safety of cangniufangjihuangqi recipe in the treatment of patients with chronic hepatitis B (CHB) cirrhosis ascites syndrome of qi deficiency and blood stasis. To provide scientific guidance for the drug effective treatment of cirrhotic patients with Qi deficiency and blood stasis syndrome of traditional Chinese Medicine. Compared with the conventional western medicine treatment Methods.Objective evaluation of traditional Chinese medicine syndrome differentiation advantage for treatment of ascites due to cirrhosis, to investigate the optimization of Integrative Medicine program. To provide an effective basis for the further development of curative effect in the treatment of ascites due to cirrhosis of clear and safe medicine.Methods60cases had been diagnosed with Qi deficiency and blood stasis type of patients with ascites due to cirrhosis, which come from the liver branch ward in Guangdong TCM hospital from2013January to2013March were randomly divided into three groups:the treatment group、the control group(1) and the control group(2), each including20cases. The cases in the control group (2) were only treated by routine western medicine, the treatment group were treated with routine western medicine adding cangniufangjihuangqi recipe, the cases in the control group(1) were treated by routine western medicine and other prescription.The treatment course of three groups for1months. Recorded the main symptoms, the symptom(Bloating, fatigue, anorexia, jaundice, edema of the double lower limbs, tongue, pulse), the Liver function, blood coagulation, blood ammonia, abdominal B ultrasound etc.Monitoring patient’s weight, abdominal circumference,24hours urine every day. observed the general medical examination for the body(for example T, P, R, BP), Blood routine, urine routine, stool routine, renal function, electrolyte, electrocardiogram, chest X-ray examination and the adverse reactions before and after the treatment, According to the condition of patients, the therapy of drawing ascites with abdominal paracentisis could be adopted in order to reduce pressure of cavitas abdominalis in three groups in necessary.After the observation had ended, Possessed all the data carry on the statistical analysis, using SPSS19.0software package, we use methods like descriptive analysis and variance analysis to analyze data. We count data by using chi-square test or rank and inspection, compare the measurement data by using T test, use the non-parametric tests on heterogeneity of variance.Result1.20cases in the treatment group, the total efficiency of95%;20cases in the control group①, the total efficiency of90%; control group②of20cases, the total efficiency of75%. By chi square test,χ2=8.533, P=0.014, P<0.05, shows the difference between the three groups in the therapeutic effect, the treatment group better than the control group. Among them, the treatment group markedly group (45.0%) and effective group (30.0%) more effective than the control group.2. The treatment group of20cases, the total efficiency of95%;20cases of control group①, the total efficiency of95%; control group②of20cases, the total efficiency of60%. By statistical analysis, the treatment group and the control group①in the total effect is statistically significant (P<0.05), the control group②in the total efficacy compared no statistical significance (P>0.05). There are differences between the three groups described the efficacy of TCM symptoms, the treatment group better than the control group. There are differences between the three groups described the efficacy of TCM symptoms, the treatment group than the control group. Among them, the TCM symptoms in the treatment group markedly group (80.0%) than in the control group improved dominant.3. The treatment group and the control group①before and after treatment change difference in anorexia, jaundice, improve have significant differences (P<0.05); the treatment group and the control group②before and after treatment changes the difference comparison, are different in fatigue, abdominal distension, chest pain, anorexia, jaundice (P<0.05); the control group ①and the control group②change the difference before and after treatment were differences (P<0.05) in fatigue, hypochondriac pain, anorexia aspects; treatment group and control group①before and after treatment in their own fatigue, abdominal distension, hypochondriac pain, anorexia, jaundice, swollen limbs were significant differences in terms of (P<0.05), the treatment group②only bloating, swollen limbs aspects were significantly different (P <0.05).4. The treatment group, the control group①in the ALT, TB, ALB and control group②had significant difference (P<0.05), which, in the above three aspects in treatment group than in the control group the curative effect is better.5. The three groups before and after self-control in weight, abdominal circumference, average24h urine, ascites and depth changes were significant differences (P<0.05). By comparing the variance paired off, we can see in body weight, abdominal circumference, average24h urine, the treatment group and the control group①were improved (P<0.05), but the treatment group is more effective, which, in the ascites indexing, the treatment group in the effect of body weight and average24h urine volume better than the control group①.6. The three groups before and after treatment in the portal vein diameter, the treatment group and the control group had obvious changes. By the statistical, there was significant difference(P<0.05), by pairwise comparison, which, by two two, the treatment group than in the control group curative effect is better. The treatment group is better than the control group in the curative effect.7.Security comparisons:After treatment three groups of Patients the general medical examination for the body, blood routine test and kidney function, ECG, all not obviously change; in the course of treatment and after treatment, also no untoward effect appears, indicating that the formula is safe and has no obvious poisonous side effect for treating liver cirrhosis ascites.ConclusionClinical observation indicate that the treatment group using the effformula to treat liver cirrhosis ascites show better iciency in curative effect improvement of symptoms resuming liver function than that in the control group and signs. In severe ascites, Weight loss, bloating improve, enhance the diuretic effect is better than the effect of YiqiHuoxue Decoction. And it also reduces the various complications, the recurrence rate, the pain and improves survival quality of life, in addition, it is safety and economy, is worthy to be popularized. The therapy of combination of Chinese traditional and western medicine has good effect on ascites due to cirrhosis. |
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