Clinical Analysis Of The Incidence Of Renal Damage And T CM Syndrome Between213Cases With New-onset Henoch-schonlein Purpura

Objective Count and analyze the incidence of renal damage in children withnew-onset Henoch-Schonlein purpura(HSP),and the relationship of TCM syndrometypes and clinical characteristic,than to identify the risk factors for renal damageamong pediatric patient with new-onset HSP.Methods The213cases with new-onset HSP treated in the first affiliated hospital ofHenan College of TCM from June2011to December2011were collected,thengrouped into HSPN-group and HSP-group.Make survey form and record clinicaldata.According to the results of the follow up,HSP-group can be divided intoA-group(with renal damage) and B-group(without renal damage).Age,gender,possiblerisk factors of renal damage were analyzed by means of univariate and multivariateLogistic regression analysis,set the inspection level P<0.05for the difference wasstatistically significant.Results (1)General information：there were124cases of male while female89casesin the213cases with new-onset HSP.Onset ages ranged from2~17years old whileaverage age was at （8.453.75） years old,and after age7(151cases) it hold71%.Infections were the main inducing factors（58.7%）,secondly respectively to eatspecial food,contact with something,vaccination,etc.The most rate in clinicalclassification was mixed type(35%),secondly respectively joint type,abdomentype,skin type.At the time of diagnosis there are23cases with renal damage,and theyare hematuria and proteinuria(9cases),simple hematuria(9cases),nephroticsyndrome(2cases),simple proteinuria type(3cases),while three children in them dothe renal biopsy.In starting symptoms,the most common was skin purpura and jointsymptoms start at the same time,secondly respectively skin purpura with abdominalsymptoms,skin purpura,abdominal symptoms,etc.(2) The distribution of TCM syndrome types in190cases of HSP-group is asfollows：86cases in blood-heat syndrome(45.3%),58cases in wind-heatsyndrome(30.5%),44cases in damp-heat syndrome（23.2%）,1cases in Yin-deficiency caused excessive Fire syndrome(0.5%) and1cases in Qi failing to control bloodsyndrome(0.5%)；after2years,There were8cases of renal damage in blood-heatsyndrome(11.6%) and3cases in wind-heat syndrome(5.9%)．(3) Followed up for2years：15cases were cured,3cases had marked effect and1case was improved in HSPN-group；HSP group followed up to166cases (24caseslost to follow up),including11cases with renal damage(6.6%),of which10cases werecured,1case got better,and the remaining155cases continued with normal routineurine.Within2years,the incidence of new-onset HSP with renal damage,a total of18.0%(with the exception of24patients lost to follow up in HSP-group),and91.2%of renal damage in HSP course of6months,and after active treatment,the incidence ofrenal damage in the new-onset HSP who initially without renal damage is6.6%.(4)The univariate analysis of possible risk factors of renal damage betweenA-group and B-group suggest that the differences of the age,skin rash(>3times),CD3(%),CD4(%),CD4/CD8indicators between the two groups have statisticalsignificance.While the multivariate Logistic regression analysis showed that skinrash(>3times)and CD4(%) were identified as risk factors to the outcome.Conclusions (1)Boys than girls are prone to the new-onset HSP,and infections werethe main inducing factors.(2) The blood-heat syndrome and wind-heat syndrome werethe advantage types of the new-onset HSP children.(3) After early interventiontreatment,the incidence of renal damage of the new-onset HSP in2years was18%.(4)skin rash(>3times)and CD4(%) were identified as risk factors for renal damage inchildren with HSP.