Study On The Relationship Between TCM Syndrome Differentiation Of CHD And The Risk Factors Such As MA And Hs-CRP

Objective:This topic was based on TCM understanding and study of coronary heart disease(CHD), combined with objective indexes of modern medical research, collected the information of four diagnostic methods, signs, modern biochemical detection indexes of patients with CHD, through the study on the relationship between TCM syndromes and objective indexes, including urinary microalbumin (MA), high sensitive C-reactive protein(hs-CRP), blood lipid(TC, TG, HDL-c, LDL-c),etc. to understand TCM syndromes distribute rule of these detection indexes data of patients with CHD, and the relationship between biochemical indexes, provide a basis for objective study of TCM syndrome differentiation of CHD.Methods:Chose120cases of inpatients that conformed to the diagnostic criteria of CHD in our hospital as the research object to make the prospective study, made an syndrome differentiation after gathering general information and diseases information of patients, to divide into four groups:heart blood stasis syndrome, syndrome of phlegm blocking heart vessel, qi deficiency and blood stasis syndrome, qi stagnation and blood stasis syndrome, then collected data of MAU, hs-CRP, blood lipid of patients to take statistics analysis.Results:1. The general situation:59patients were male,61female patients, there was no significant difference about sex in various syndromes (p>0.05); the average age of the patients with qi deficiency and blood stasis syndrome was the highest (p<0.05).2. Syndrome differentiation:42patients with heart blood stasis syndrome,36patients with syndrome of phlegm blocking heart vessel,22patients with qi deficiency and blood stasis syndrome, and20patients with qi stagnation and blood stasis syndrome, there was a significant difference among the number of various syndromes (p<0.05), i. e., sort by the number of cases:heart blood stasis syndrome> syndrome of phlegm blocking heart vessel> qi deficiency and blood stasis syndrome> qi stagnation and blood stasis syndrome.3. Urinary microalbumin(MA):heart blood stasis syndrome and qi deficiency and blood stasis syndrome were the most in MA-positive patients, qi stagnation and blood stasis syndrome was the least, there were significant differences in the number of cases (p<0.05); there was no significantly difference in MA level among various syndromes (p>0.05). After removing the two abnormal deviation, there was significant difference between heart blood stasis syndrome and the other syndromes(p<0.05), i.e., heart blood stasis syndrome was higher than the other syndromes, besides, female has higher MA level than male(p<0.05).4. High sensitive C-reactive protein(Hs-CRP):heart blood stasis syndrome was the most in (Hs-CRP)-positive patients, the next, syndrome of phlegm blocking heart vessel> qi deficiency and blood stasis syndrome> qi stagnation and blood stasis syndrome (p<0.05);Hs-CRP level:heart blood stasis syndrome and syndrome of phlegm blocking heart vessel> qi stagnation and blood stasis syndrome> qi stagnation and blood stasis syndrome (p<0.01).5. Blood lipid:TC distribution in these syndromes, syndrome of phlegm blocking heart vessel> heart blood stasis syndrome> qi stagnation and blood stasis syndrome> qi deficiency and blood stasis syndrome, through the analysis of variance, there was significant differences(p<0.05);TG distribution in these syndromes, through the analysis of variance, there was no significant differences(p>0.05);HDL-c distribution in these syndromes had no significant difference in these syndromes (p>0.05);LDL-c levels of heart blood stasis syndrome, syndrome of phlegm blocking heart vessel, qi deficiency and blood stasis syndrome were significantly higher than qi stagnation and blood stasis syndrome(p<0.05); but there was no significant difference between the three groups (p>0.05)6. Correlation among MA, Hs-CRP and blood lipid:the correlation coefficient of MA, Hs-CRP and blood lipids was less than0.2, there was no significants correlation among blood lipid, MA and Hs-CRP; the correlation coefficient of Hs-CRP, TC and LDL-c was greater than0.6(p<0.05), so there was significants correlation among the three.Conclusion:The most common syndrome in patients with coronary heart disease is heart blood stasis syndrome, and the levels of MA of patients with heart blood stasis syndrome are higher than the others, the levels of hs-CRP and LDL-c of patients with heart blood stasis syndrome and syndrome of phlegm blocking heart vessel are also higher than the others, this suggests that the systemic endothelial function of patients with heart blood stasis syndrome is more serious than the other three syndromes, also shows that the risk factors(vascular inflammatory reaction, blood lipid, etc.)of patients with heart blood stasis syndrome are more serious than other syndromes. There is no significant correlation among MA, Hs-CRP and blood lipid; there is significantly positive correlation among Hs-CRP, TC and LDL-c.