Simple Obesity In Children With Plasma High-sensitivity C-reactive Protein And Cardiovascular Disease Correlation Of Risk Factors

Objective: To study the relationship between the plasma of obese childrenhypersensitive C-reactive protein and cardiovascular disease, namely the role ofhs-CRP in cardiovascular disease and the value in the diagnosis, evaluation ofcardiovascular events, explore the ultra-sensitivity C-reactive protein associated withcardiovascular disease risk factors.Methods：Select from October2012to February2014for treatment of obese children inour hospital pediatric clinic in37patients, including20males and17females.Referring to China Obesity Working Group classification criteria to determine obesity,over weight or body mass index of20%(BMI)≥25. According to whether abnormalblood pressure, hypertension divided into groups and non-hypertensive group.26cases in the control group of children,15males and11females, their body weightwithin the standard range or body mass index (BMI)<25. Record general information,height, weight and age, sex, blood pressure measurement. Biochemical markers byimmunohistochemistry assay for total cholesterol (TC), hypersensitivity measured CRP(hs-CRP total triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein(LDL), immunochromatography). Measurement of carotid intima-media thickness:jointly completed by the same B-room two senior medical professionals, the choice ofthe probe frequency is7.5-10.OMHz Siemens2000color Doppler ultrasonography tomeasure carotid intima patients media thickness (IMT). Record the results of all theindicators measured. Result：1．The average age of children obese group (11.54±110.) Years of age and the averageage of children in the control group (11.31±1.05) compared with the age differencewas not statistically significant (P>0.05); obese children’s average height (1.69±0.07)m and the average height of children in the control group (1.68±0.07) m compared, thedifference was not statistically significant (P>0.05); average weight of obese childrenwas (85.31±9.34) kg average weight of children in the control group (59.80±7.19) kgcompared, the difference was statistically significant (P <0.05); obese childrencompared with control group sex (χ2=0.81<3.84), the difference was not statisticallysignificant (P>0.05).2. Median obese children in hs-CRP was2.82mg/L and the control group of childrenmedian hs-CRP0.55mg/L compared, the difference was statistically significant (P<0.05); BMI obese children median29.3821.38compared with the median BMI ofchildren in the control group, the difference was statistically significant (P <0.05); IMTmedian IMT obese children as the control group median0.57mm children0.46mmcompared, the difference was statistically significant (P <0.05).3. Obese children in total cholesterol (TC) with an average of (169.72±29.62) mg/dltotal cholesterol and control group mean (121.5±16.03) mg/dl compared, thedifference was statistically significant (P <0.05); obesity group of children of lowdensity lipoprotein (LDL) average of (105.44±37.60) mg/dl and LDL control group(LDL) mean (80±17.36) mg/dl compared, the difference was statistically significant(P <0.05); obese children in high density lipoprotein (HDL) average of (45.28±15.02)mg/dl in the control group and the high density lipoprotein (HDL) mean value (57.09±10.66) mg/dl compared to the difference was statistically significant (P <0.05); obesechildren in total triglyceride (TG) with an average of (147.94±64.05) mg/dl andtriglycerides mean control group (124.07±48.24) mg/dl comparing the difference wasnot statistically significant (P>0.05).4. Hs-CRP in obese hypertensive group median of3.60mg/L and non-hypertensivegroup median hs-CRP2.48mg/L compared, the difference was statistically significant (P <0.05); obese children in the hypertensive group IMT median of0.60mm comparedwith non-hypertensive group IMT median0.50mm, the difference was statisticallysignificant (P <0.05).5. Obesity plasma hs-CRP levels and systolic blood pressure (SBP), diastolic bloodpressure (DBP), total cholesterol (TC), total triglyceride (TG), low density lipoprotein(LDL), carotid intima-media thickness (IMT) was positively correlated (P <0.05), andplasma high density lipoprotein (HDL) levels were negatively correlated (P <0.05).Conclusion：1. In obese children, plasma concentrations of hs-CRP were significantly higher thannormal children, and was significantly associated with carotid intima-media thickness,indicating that serum high-sensitivity CRP involved in carotid atherosclerosis formation,as a predictor of cardiovascular disease in obese children indicators of risk factors.2. In obese children, the performance of children with hs-CRP levels weresignificantly increased, increased carotid intima-media thickness, indicating that highblood pressure can contribute to the formation of atherosclerosis, is a risk factor foratherosclerosis. Changes in levels of high-sensitivity CRP and the severity of essentialhypertension is closely related to one of the indicators can react earlier hypertensiondisease.