Clinical Observation Of Zhuang ShenLing Acupoint Drug Combined With Hormone In Treatment Of Primary Nephritic Syndrome

ObjectiveThe Clinical efficacy of traditional Chinese medicine Zhuang ShenLing through the acupoint drug combined with hormone on spleen and kidney yang deficiency type of primary nephritic syndrome, as Integrated Traditional and Western treatment of this disease, enhance the efficacy of hormones, reduce adverse reactions in patients with long-term use of hormones, delaying the disease progress in providing new treatments and methods.MethodsSelection on January1,2013-December30,2013, the first one in Zhanjiang hospital outpatient and (or) ward diagnosis of spleen and kidney Yang deficiency type patients with primary nephritic syndrome, In medical order50patients were randomly divided into the treatment group, control group every25cases, upon examination in the two groups in age, sex and course no statistical difference (P>0.05). Control group given low salt low fat high quality protein diet, standard hormone therapy and decreasing dosage (initial prednisone,1mg/(kg/d), a meal in the morning,4～8weeks after gradually reduced, usually a week5mg, reduced to0.5mg/(kg/d), keep taking3～6months), used in the clinical symptomatic treatment measures, including infection control, water electrolyte disorder, regulate blood lipid and other related factors control. Treatment group in the control group on the basis of spirit to join at the same time complementary with strong kidney t2dm treasure topical medicine kidney acupoints on acupuncture points, treating30minutes, once a day. Two groups were treated for eight weeks, compare two groups of24hours urinary protein quantitative, plasma albumin, blood fat, comprehensive curative effect of western medicine, Chinese medicine symptom curative effect, Chinese medicine symptom integral, and observe what is happening during the treatment side effects of hormone, thus research spirit strong kidney meridian through medicine in the treatment of the disease. For the processing of the results using SPSS13.0statistical software, measurement data with mean+standard deviation, said mean comparison between groups using t test, count data comparison with x2test, hierarchical data comparison with rank and inspection, hypothesis test and unified use bilateral test, P<0.05was statistically significant.Results1. Comprehensive of Comparison efficacy:Zhuang Shenling combined hormone treatment group25cases, completely relieve the basic ease in5cases,10cases,7cases effectiveness,3cases, treatment group total effective rate was88.00%; Simple hormone control group25cases, complete remission3cases, basic ease in5cases,8cases effectiveness and9cases, control group total effective rate was64.00%. Comparing the two groups was statistically difference (P<0.05), treatment group effectiveness is higher, shows strong Zhuang ShenLing combined hormone treatment group curative effect superior to simple hormone control group.2. Comparison of efficacy of TCM syndrome:The two groups before treatment of traditional Chinese medicine symptom integral is statistically (P>0.05), the two groups after treatment of TCM symptom score than before treatment (P<0.05), two groups of points of difference comparison also has statistical significance (P<0.05). That simple hormone and Zhuang ShenLing combined hormone can to a certain extent improve edema, lumbar acid, such as clinical syndrome, treatment group points difference is bigger, so the Zhuang ShenLing combined hormone effect superior to simple hormone therapy. The two groups before treatment of traditional Chinese medicine symptom integral is statistically (P>0.05), the two groups after treatment of TCM symptom score than before treatment (P<0.05), two groups of points of difference comparison also has statistical significance (P<0.05). That simple hormone and Zhuang ShenLing combined hormone can to a certain extent improve edema, lumbar acid, such as clinical syndrome, treatment group points difference is bigger, so the Zhuang ShenLing combined hormone effect superior to simple hormone therapy. 3. Comparison of The Chinese medicine symptom:the two groups before treatment of traditional Chinese medicine symptom integral is no statistical significance (P>0.05), after treatment of TCM symptom score than before treatment (P<0.05), two groups of integral differential comparison also has statistical significance (P<0.05). That both treatments are to a certain extent improve edema, lumbar acid, such as clinical syndrome, but the treatment group is better than the control group.4.Comparison of biochemical markers:the two groups before treatment and24hours urinary protein and blood lipid, plasma albumin quantitative differences no statistical significance (P>0.05), compared with before treatment after treatment of statistical significance (P<0.05), the two groups can reduce the24hours urinary protein quantitative and improve plasma albumin, reduce blood fat; Plasma albumin, blood fat difference between two groups after treatment was no significant difference (P>0.05),24hours urinary protein quantitative after treatment in treatment group and control group was statistically significant (P<0.05). That the treatment group in reducing24hours urinary protein quantitative curative effect is superior to the control group.5.Security Watch:before and after treatment of blood, stool, blood glucose, liver function, kidney function was no significant difference (P>0.05), the treatment group during treatment of acne, infections, hormonal side effects, such as central obesity significantly lower than the control group. Description Zhuang ShenLing combined hormone kidney-toxic, safe, and significantly reduce the side effects of hormones.Conclusion1. Zhuang ShenLing through the acupoint drug combined with hormone on spleen and kidney yang deficiency type of PNS can significantly reduce the24-hour urinary protein excretion.2.Zhuang ShenLing through the acupoint drug combined with hormone on spleen and kidney yang deficiency type of PNS can significantly improve edema, lumbar acid, lack of power, in appetence, clinical symptoms.3.Zhuang ShenLing through the acupoint drug combined with hormone on spleen and kidney yang deficiency type of PNS can enhance efficacy, reduce side effects of hormones. 4. Zhuang ShenLing through the acupoint drug combined with hormone on spleen and kidney yang deficiency type of primary nephritic syndrome comprehensive clinical application found no obvious side effects, there are actually use value, worthy of clinical promotion.