Clinical Observation Of Nourishing Spleen And Kidney And Activating BloodFlow On Hypercoagulability Of Primary Nephritic Syndrom

Objective:Hypercoagulability of Primary Nephritic Syndrom is the main reason of thrombotic disease. It was also the major cause of the progressive development into the End Stage Renal Disease (ESRD), and influenced prognosis. This study is to evaluates the clinical effect of nourishing spleen and kidney and activating blood flow by observing the efficacy of TCM with Western Medicine on 40 patients with hypercoagulability of Primary Nephritic Syndrom.Methods:(1)40 patients with hypercoagulability of Primary Nephritic Syndrome and spleen-kidney qi deficiency syndrome with blood stasis syndrome were divided randomly into two groups,the control group and the observation group. Each group had 20 cases. All the patients were recruited from September 2013 to September 2014 in Wuhan Intergrated TCM and Western Medicine Hospital outpatient and inpatient;(2)The control group were given western conventional therapy:Prednisone(or Methylprednisolone)+CTX;the observation group were treated with Integrated TCM and Western therapy:western medicine+Chinese medicine(Decoction for Jisheng Shenqi and Decoction for Removing Blood stasis in chest);(3)To compare The 24 hours urinary protein quantities. Albumin、Triglyceride、Serum creatinine、24 hours urinary volume、Platelet count、Fibrinogen、 Fibrin degradation product、Cholesterol、Prothrombin Time、 Activated partial thromboplastin time、D-2dimmer、symptomatic scores of TCM and side effects between the two groups before and after treatment. (4)A11 data was recorded by using SPSS 19.0 software for statistical analysis. T test was conducted for comparison intragroup and intergroup. There was no statistical difference when P value was greater than 0.05.Results:(1) Statistical analysis showed that there was no significant difference between the control group and the observation group in terms of sex、age、duration and pathologic distribution. (2)The cure rate of the observation group (90%) was better than the control group’s(75%),with statistical difference (p<0.05). (3)The TCM symptoms of the observation group improved much more than the control group after treatment,with significant difference (P<0.01);(4)The index of Primary Nephritic Syndrome:the 24 hours urinary protein quantities、Triglyceride、Serum creatinine level of both group was decreased after treatment,but Albumin, 24 hours urinary volume level of both group increased after treatment,all with significant differences(all P< 0.05), the observation group improved more than the control group (P<0.05). (5) The index of Hypercoagulability with Primary Nephritic Syndrome:Platelet count、Fibrinogen、Fibrin degradation product. Cholesterol、Prothrombin Time、Activated partial thromboplastin time、D-2dimmer level of both group improved significantly after treatment (all P<0.05), the observation group improved more than the control group (P< 0.05). (6) The observation group had more advantages in reducing acne vulgaris and decreasing nervous system hyperexcitability(P<0.05).Conclusions:Through the clinical observation,we finally draw the conclusion that nourishing spleen and kidney and activating blood flow had the obvious efficacy in treatment of hypercoagulability with Primary Nephritic Syndrome. And it also could improve virious indexes of Primary Nephritic Syndrome.