| ObjectiveChronic glomerular nephritis is the primary in a group of autoimmune diseases, immune-mediated renal injury is a key part of the pathological process, corticosteroids and immunosuppressive agents in the treatment of chronic nephritis plays an important role. However, due to the special nature of kidney disease, chronic nephritis treatment is a long-term process, the use of large doses of immunosuppressant, long course of treatment, the treatment process is difficult to avoid in patients with immune dysfunction, concurrent infection, and sometimes even fatal harm. Need to seek a solution immunosuppressant hormone causes the immune disorders in clinical measures. Studies have shown that Chinese medicine can regulate immune function in patients with chronic nephritis, but with traditional Chinese medicine, diagnosis and treatment coverage as much, and moxibustion applied to chronic nephritis have not been reported in the literature. Clinical practice and experimental studies in recent years have confirmed:moxibustion and immune function has its inherent relationship to healthy immune function, bi-sexual adjusted so that the body’s organs and organ functional activities of different systems transformed from an abnormal state to the normal state. And moxibustion has a simple, convenient, experience, honesty characteristics. The purpose of this study is to observe the changes after chronic nephritis patients after moxibustion Shenque, Guan Yuan, air sea after acupuncture treatment-related laboratory parameters, moxibustion for such patients to explore the role of regulation of immune function. To regulate the immune function of chronic nephritis provides a new ways and ideas. MethodsKidney Disease Hospital of Guangdong deep into the clinic from March2013 to December2013period in line with chronic glomerulonephritis patients in this study required by the random number table, randomly assigned to group A and group B. Group A and Group B are to be the basis of the treatment of chronic nephritis, use of hormone therapy or immunosuppressive agents caught in accordance with standard use. Group A:1-4weeks:maintain basic therapy moxibustion treatment observation, acupoints:Shenque, air sea, Guan Yuan. Suzhou plant with clear moxa moxa moxa lit into me, after laying thick skin towel placed on acupuncture points to warm feeling no pain is appropriate for the degree of skin flushing every15-20minutes per therapy three times a week, four weeks for a course.5-8weeks to maintain the basic treatment observation. Group B:1-4weeks to maintain the basic treatment observation.5-8weeks:maintain basic therapy Moxibustion treatment observation Respectively, before enrollment (pre-moxibustion therapy), moxibustion treatment after4weeks at the end of treatment were detected following items: blood, serum creatinine, blood urea nitrogen, calculated GFR; T cell subsets (including CD3, CD4, CD8), immunoglobulins (IgA, IgG, IgM), complement C3. Clinical observation and input table. Basic information using Excel to build a database, the data import SPSS19.0software package for statistical analysis. Results1. The study included from March2013to December2013period in patients with chronic glomerulonephritis meets the requirements of the study of31cases, including4males and13.3%females,26cases (86.7%), the oldest person63years old, the smallest in24years, the average age was41.23±11.7years old,16patients randomized into Group A, Group B were randomized into15cases, including2cases of patients treated by the fall, not included in the study patients, who eventually included in the statistics a total of29cases2. Period effects:Patients CD3, CD4, CD4/CD8, IgA, IgG, IgM, complement C3, LYM, BUN, Scr, urine occult blood, protein in urine mean difference effect comparison between two different sequence groups, the difference no statistically significant (P>0.05), suggesting that the study of the efficacy of treatment for patients with these indicators may not be present during the effect; patient CD8compare the efficacy of the average difference between the two groups in a different order, the difference was statistically significant (P=0.035), there may prompt treatment effects at various time periods3. Does not consider the effect of the comparison period:Patients CD3, CD4, CD4/CD8efficacy of two treatment mean difference, the difference was statistically significant (P<0.05), its efficacy is the average difference are positive, a prompt treatment of patients with CD3, CD4, CD4/CD8effects processing is elevated compared to B, that is the basis of moxibustion therapy+treatment than a simple basic treatment for CD3, CD4, CD4/CD8affected patients was elevated. For patients with IgA, IgG, IgM, complement C3, LYM, BUN, Scr, urine occult blood, urine protein compare the efficacy of the difference, the difference was not statistically significant (P>0.05).4. The effect of the correction period effect after comparison:compare the efficacy of two patients treated CD8mean difference, the difference was not statistically significant (P=0.05), there may be some impact on the two treatments in patients CD8, patients in both groups CD8mean difference effect are negative, suggesting that moxibustion+-based therapy compared to simple basic treatment for affected patients may be reduced CD8.5. Residual effects:the efficacy of both treatments in patients and the mean comparison between the two groups, the difference was not statistically significant (P>0.05), prompted moxibustion treatment for patients with chronic glomerulonephritis in the during the study period may temporarily exclude residual effects. ConclusionMoxibustion Meridian on patients with chronic peripheral blood T lymphocytes CD3, CD4, CD4/CD8significantly higher effect on CD8cells have a reduced role in the content, you can adjust the patients with a certain degree of T lymphocytes cells, while patients with normal immune globulin and complement C3is not obvious that a certain degree of immune function and adjust the disordered state to the normal state, this may be one of the mechanisms regulating moxibustion patients with chronic immune glomerulonephritis. For patients with chronic glomerulonephritis, serum creatinine, blood urea nitrogen, urine protein and urine occult blood effects are obvious, which may be affected by the research time and intensity of treatment, and further in-depth research and analysis of specific principles to be. |
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