The Correlation And Clinical Significance Of Expression Of EBP1and P53in Cervical Carcinoma

Objective:Cervical cancer is one of the most common malignant tumor of female breast cancer in women, become the second most common female malignant tumor. Epidermal growth factor and its receptor (EGFR) in tumor occurrence, development is closely related to, and Ebp1was found in recent years, the new ErbB3binding protein associated with cell growth, proliferation. Our previous study found that the high expression of Ebp1in cervical carcinoma tissues, but its in cervical cancer and its mechanism of action has not been reported. Therefore, to observe the expression of Ebp1in cervical cancer cell lines and tissues in this study, further testing P53protein expression in cervical cancer, and analyze the correlation between the expression of P53and Ebp1protein and clinical pathological parameters of cervical cancer and their correlation, to provide the experimental basis for the treatment of cervical cancer targeted drugs.Methods:the expression of Ebp15in cervical cancer cell line in vitro protein are first detected by Western blotting, were used to detect the expression levels of Ebp1and P53protein in30cases of cervical carcinoma tissues and its adjacent tissues using immunohistochemical SP method, and the abnormal expression of two protein in cervical cancer tissues were analyzed the correlation and clinical significance.Results:the positive expression of Ebp1in cervical cancer cells, P53protein and the positive rates of Ebp1protein in cervical cancer (60%,33.3%) is significantly higher than the positive rate of P53protein and Ebp1protein in the cancer tissue (6.7%,3.3%)(P<0.05). Has nothing to do with the patient age, tumor size, family history of P53and Ebp1protein expression in cervical cancer tissues, high expression of P53and Ebp1and tumor TNM stage and lymph node metastasis were positively correlated (P<0.05). Conclusion:the high expression of1.Ebp1in cervical cancer cells in culture and P53;2.Ebp1protein expression in cervical cancer was higher than that in the tumor adjacent normal tissues; the expression of3.Ebp1and P53protein and cervical cancer TNM staging and lymph node metastasis; expression of4.Ebp1and P53protein in cervical cancer with a positive correlation, the intervention of Ebp1signal access link, may provide pharmacological target for targeted therapy of cervical cancer.