Analysis Of Risk Factors For Diabete Patients Suffering From Cognitive Dysfunctions

ObjectiveIn order to explore risk factors of Northern Chinese Han diabete population suffering from cognitive dysfunctions, and provide theoretical basis for disease diagnosis, prevention and treatment.MethodWe collected a total of100type2diabete cases from Sep.2012to Dec.2013, all of which were from Tianjin Medical University Hospital. Cognitive functions of patients were assessed by combination of simple intelligence Mental State Examination (MMSE), clinical cognitive dysfunction scale (Clinical Dementia Rating, CDR) and overall Deterioration Scale (Global Deteriorate Scale, GDS).Statistic analysis was performed by SPSS17.0software and GraphPad Prism software.ResultAge of all samples ranged from42to80years old, with a mean of61±11years old. A total of43type2diabete cases suffered from cognitive dysfunctions (43%), of which20were male and23female. Duration time of diabete ranged between1-27years, with a mean of11.5±8years, and chi-square test showed that the longer the duration time, the higher the risk of diabete cases suffering from cognitive dysfunction (x2=30.213, df=4,p＜0.001).High education level could reduce the risk of diabete cases suffering from cognitive dysfunction (x2=10.817, df=4, p=0.029).Comorbidity with kidney disease (x2=6.656, p=0.01),lipid metabolic disorders (x2=8.3,p=0.004), cerebral infarction (x2=7.217,p=0.007), digestive diseases (x2=4.456, p=0.035) risk hyperviscosity (x2=17.993,p<0.001), or obesity (x2=6.221, p=0.013) in patients with diabetes could significantly increase the risk to suffer from cognitive impairment.Biochemical analysis showed that, when compared to patients with diabetes only, diabetic patients with cognitive dysfunction exhibited higher systolic blood pressure (mmHg)(t=4.415, p＜0.001), total cholesterol (mmol/L)(t=2.149, p=0.034) and glycated hemoglobin (%)(t=2.969, p=0.004). However, high-density lipoprotein levels (mmol/L) was significantly lower (t=5.014, p<0.001) in diabetic patients with cognitive dysfunction.ConclusionLow educational level and long duration of diabetes are two risk factors of diabetic patients sufferring from cognitive dysfunction.Lipid metabolism imbalance may increase the risk of diabetic patients suffering from cognitive dysfunction. Other risk factors included hypertension, obesity, diabetic nephropathy, diabetic peripheral neuropathy, and family history of diabetes. The present study provided theoretical basis for disease diagnosis, prevention and treatment.