| ObjectivePulmonary infection is one of the common diseases in elderly people, according to statistics, more than16%of the elderly directly die of lung infection, and this risk tends to increase with age. Therefore, the early diagnosis, treatment and assessment of this disease are crucial. By collecting the clinical data of pulmonary infection group and control group and measuring the levels of variables like APN and CRP respectively, this study aims to investigate the changes of APN’s level in pulmonary infection and associated with pulmonary infection. In order to provides the basis for clinical diagnosis and condition monitoring, as well as establish a simple yet effective diagnosis and monitoring method of change state of the illness for clinicians.MethodsThe experimental group consisted of70persons (each above60years) with Community-acquired pneumonia or Hospital-acquired pneumonia, who were selected from those staying at our hospital from April2012to June2013. Based on related diagnostic criteria,27cases among them belong to the severe group, while the rest43make up the mild group. And the control group consisted of20healthy controls (each above60years old) coming from our physical examination center in the same period. Besides, Enzyme Linked Immunosorbent Assay was used to detect the level of APN, and Immunoturbidimetric Assay for detecting CRP level and observing the changes of APN and CRP levels.Results(1) Compared with the control group, the levels of N%and WBC of the infected group were apparently higher with statistical significance(P<0.05), while the others were not significantly different (P>0.05)(2) Compared with the control group, the levels of serum APN of the mild and the severe groups were significantly lower [(8.89±1.93) mg/L vs (6.79±1.87) mg/L vs (4.89±1.13) mg/L,P<0.05]; Compared with the mild group, the levels of serum APN of the severe one were significantly lower [(6.79±1.87) mg/L vs (4.89±1.13) mg/L,P<0.05]; Compared with the control group, the levels of CRP of the mild and the severe groups were significantly higher[(1.69±1.12) mg/L vs (13.38±3.07) mg/L vs (18.41±4.6) mg/L,P <0.05];Compared with the mild group, the levels of CRP of the severe one were significantly higher [(13.38±3.07) mg/Lvs (18.41±4.6) mg/L,P<0.05].(3) With active treatment, both the mild and the severe groups see an increase in the levels of serum APN by about41.1%and20%respectively, which difference was of statistical significance(P<0.05); on the other hand, the levels of CRP were reduced by about64.3%and60.1%respectively, which was also statistically significant(P<0.05).(4) Correlation Analysis reveals a negative correlation between APN and CRP、SBP、 DBP, Correlation coefficient were-0.534、0.420、0.266,respectively.(5) Multiple stepwise regression analysis showed that after exclusion of influence of various factors, CRP and SBP were the independent influence factors of APN. Regression equation:APN=3.051-0.181CRP+0.043SBP.(6) Stepwise Logistic regression analysis showed, APN was the independent influence factors for pulmonary infection in the elderly.Conclusions(1) The study find out the dynamic nature of APN level in the progression of pulmonary infection, and APN was closely related to the development of pulmonary infection which was probably one of the independent influence factors for the pulmonary infection.(2) APN may be a new anti-inflammatory cytokine. (3) It helpful as a new symbol to diagnose and monitor the elderly with pulmonary infection. |
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