| Background Geriatric Depression is the most common mental disorder in the old age.Except for mood disorders in patients with depression, it is also always accompanied by cognitive function disorders, performing the overall brain function damage, especially characterized by executive dysfunction in the frontal lobe damage.Cognitive dysfunction can be evaluated by the event related potential P300objectively.The GoP300and NogoP300waveforms can be obtained by the Go/Nogo competition reaction detection.The principal component of GoP300is GoP3and the principal component of NogoP300are NogoN2and NogoP3. The attention of executive function can be assessed by GoP3.NogoP3is associated with response inhibition, NogoN2reflects the inhibitory executive function.Although it is widely recognized NogoN2, NogoP3can reflect the executive function,there is no unified reported on the specific characteristics of different groups.At the same time,there is also a big controversy on if it can be one of the indexes of judging the prognosis in patients with depression. Therefore, this research will select Go-P3, NogoP3, NogoN2as the main research targets.Objectives Try to discuss the characteristics of executive function in patients with geriatric depression through testing the P300, at the same time,prove whether Nogo prepositional effect exists in the older population.Compare the index changes of P300of the geriatric depression patients before and after treatment, discuss the significance and influence factors of executive function,then provide the objective basis for the diagnosis and treatment of geriatric depression.Methods (1) Confirm the researching group and comparing group.The researching group were30cases first fall geriatric depression patients accord with the DSM-Ⅳ diagnosis standard. The comparing group could be①elderly health group：choose30normal elderly people with the team in age, sex and culture basic matched to the researching group, and with a healthy body, no alcohol, tobacco, hobby and no history of psychiatric disorders;②Young and middle-aged depression group:choose30young and middle-aged patients with depression diagnosed with DSM-Ⅳ standard;③Young and middle-aged health group:choose30normal young people a healthy body, no alcohol, tobacco, habits and no history of psychiatric disorders,age, sex and cultural basic matched to the young and middle-aged depression group.(2) The blood routine, electrocardiogram, liver function and kidney function were checked in all of the groups, P300and MMSE were determined in the researching group and all the control groups respectively.The researching group and young and middle-aged depression group adopt antidepressant treatment for6weeks,during the study period, other antidepressants and antipsychotic therapy were forbidden,and eliminated the patients who could not tolerate,determined P300respectively in the researching group and middle-aged and young control group after treatment for6weeks.The researching group and young and middle-aged depression group were measured by HAMD before and after6weeks treatment, and evaluated the effect with HAMD scale score points,the effective rate was50%or higher, points rate<50%rating was invalid.(3) Analysis all the data summary and statistical by SPSS19.0statistical software.All data were reported by the way of "mean±standard deviation"(x±s),and all the data were for normality test, research data comparison before and after the treatment with paired t test or paired comparison rank and inspection.Pearson was used to analysis the correlation of the data,.P<0.05was considered statistically significant difference.Results (1) In the researching group,the NogoP3latency was greater than the GoP3latency, the amplitude was higher than the GoP3amplitude, but there were no statistically significant difference (P>0.05).(2) Compared to the middle-aged and young healthy group, the NogoP3latency period of the elderly healthy group was greater(P<0.05), amplitude was reduced with significant statistic difference(P<0.05).The NogoN2latency period of the elderly healthy group was greater with significant statistic difference (P<0.05),but the NogoN2amplitude of the elderly healthy group was lower with no significant statistic difference (P>0.05).(3) Before drug intervention,compared to the elderly healthy group,the NogoP3latency period of the researching group is greater.the amplitude is lower with significant statistic difference (P<0.05). The NogoN2latency period of the researching group is greater with significant statistic difference (P<0.01),the amplitude is lower with significant statistic difference (P<0.05).Compared to the young and middle-aged depression group,the NogoP3latency period of the researching group is greater with significant statistic difference (P<0.05),but the amplitude is lower with no significant statistic difference (P>0.05). The NogoN2latency period of the researching group is greater with significant statistic difference (P<0.05),but the amplitude is lower with no significant statistic difference (P>0.05).(4) After drug intervention for six weeks, the NogoP3latency period of the researching group was shorter, the amplitude increased with significant statistic difference (P<0.05). The NogoN2latency period of the researching group was shorter, the amplitude increased with significant statistic difference (P<0.05).Compared to the elderly healthy group,the NogoP3latency period and the NogoN2latency period of the researching group were both greater and lower with significant statistic difference (P<0.05).Compared to the young and middle-aged depression group,the NogoP3latency period and the NogoN2latency period of the researching group were both greater and lower with significant statistic difference (P<0.05).(5)The degree of depression may be associated with the prognosis of executive function in the geriatric depression patients.Conclusions Nogo prepositional effect disappeared in elderly patients with depression;2.There were obvious executive function disorders in elderly patients with depression, aging may enhance the executive function disorders, and influence the improvement of the executive function;3.The executive function in patients with senile depression could be improved by drug intervention,but the effect may be influenced by aging;4.The degree of depression may be associated with the prognosis of executive function in the geriatric depression. |
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