The Research Of Executive Function And Event-related Potentials In Patients With Mild Cognitive Impairment

Objective:In recent years，there are more researches on theepisodic memory and attention function in patients with MCI，and the researchof executive ability in MCI patients is relatively less and the conclusion isdifferent,Whether patients with MCI have the ability to perform damage andexecutive function is damaged or local damaged, and whether event relatedpotentials can help early diagnosis are worth exploring. The purpose of thispaper is to discuss whether the three core executive function in patients withMCI component is damaged, the correlation of event related potentials andexecutive function impairment in patients with MCI. Looking for the earlyrecognition of MCI implementation of objective function, improve the level ofearly diagnosis of mild cognitive impairment. Methods:60cases of researchobjects, divided into MCI group of30cases,30cases in the control group. MCIpatients met the diagnostic criteria of mild cognitive impairment ofPetersen.The control group consisted of30age, education level, gender andMCI matched healthy elderly. All subjects completed the following test andtasks:1, neuropsychological scale test: Montreal cognitive scale (MoCA),Mini-mental state examination (MMSE), clinical dementia rating scale (CDR),Auditory verbal learning test (AVLT), Clock-drawing test (CDT), Trail MakingTest (TMT);2, computer auxiliary test: John stroup experiment (Stroop test),"2-the back task";3, the determination of event related potential: mismatch negative wave (MMN) and P300. Results：1. Evaluation of the overallcognitive function in patients with mild cognitive impairment: MCI group withage, gender and education matched compared between the normal controlgroup，the MMSE score was significantly decreased (P<0.01), and the MoCAscore decreased significantly (P<0.01), MoCA to delay memory, visual space,executive function damage is given priority to.2.The executive functionassessment:2.1TMT test evaluation task switching function, MCI patientscompared with NC group of patients, the TMT-B significantly prolonged (P <0.01), the interference quantity increased (P <0.01)2.2Clock-drawing testevaluation of executive function in action planning and anti-interferenceability,compared with NC group of patients,MCI patients score wassignificantly decreased (P <0.01)2.3computer aided test "2-the back task"assessment the refresh of working memory, results show that the MCI patients"2-the back task" error rate is significantly higher than normal group (P <0.01)2.4computer aided test stroop task assessment of response inhibition, MCIpatients compared with NC group, under the condition of conflict, extendedMCI patients with reaction time, reaction time disturbance variable extension inthe normal group (P <0.01), number of correct interference quantity is less thannormal group (P <0.01)3. The event related potential detection: latency ofP300and MMN in patients with MCI patients is significantly longer than NCpatients (P <0.01), amplitude of P300and MMN in patients with MCIpatients is significantly decreased (P <0.01)4. The correlation of neuropsychology and the event related potential in MCI:Reaction of MMN andP300latency delay and stroop interference quantity,TMT interferencequantity, error rate of the2-back task into positive correlation, and correctstroop interference quantity into negative correlation; MMN and P300amplitude reduce reaction time with stroop interference quantity, TMTinterference quantity, error rate of the2-back task is negative correlation, andcorrect stroop interference quantity into positive correlation.Conclusion:1,Evaluation results general cognitive function in patients with mild cognitiveimpairment: delayed memory, executive functions, visual spatial attention,damage, and MoCA is a better evaluation of mild cognitive impairmentassessment tools.2, computer aided inspection: Stroop task (response inhibitiontask), n-back (working memory) and paper-and-pencil tests:TMT test (taskswitching) showed mild cognitive inhibition, working memory impairment inpatients with reaction, task switching function are damaged, executive functionoverall damage.3, event related potential P300and MMN and Stroop task,n-back task, attachment test has good correlation, and can be used as a mildcognitive dysfunction in patients with early response executive functionimpairment of nerve electrophysiology index.4, MMN, P300andneuropsychological tests together will greatly enhance the diagnosis of mildcognitive impairment in patients with executive dysfunction.