Risk Factors Of Anxiety And Depression In Ulcerative Colitis

Objective: This study was to explore whether the patients with the Chinese crowdulcerative colitis (UC), compared with general population, is prone to anxiety,depression, and abnormal mental mood; To study anxiety, depression and other mentalabnormality associated risk factors in UC patients, aiming to provide psychologicalintervention to UC patients with anxiety, depression and other mental abnormal as soonas possible and provide theoretical basis for psychological treatment.Methods:100patients with UC from December2012-December2013were collected indepartment of Gastroenterology、bowel disease center in Beijing military region generalhospital. Patients with UC were assessed of general situation questionnaire(collectingpatients’ age, culture level, occupation, treatment adherence, disease types,glucocorticoid treatment such as basic situation made), ZUNG depression selfrating-scale, ZUNG anxiety self-rating anxiety scale and social support rating scale,inflammatory bowel disease questionnaire. All scores were compared by SPSS17.0statistics, P<0.05was considered to have statistic difference, p<0.01was considered tohave significant statistic difference.Results: By t test and X2test and unconditioned Logistic regression analysis, anddisplay: Anxiety and depression scores in UC patients compared with domestic norm:Compared with national norm (P=0.00,P<0.05), anxiety and depression scores havestatistic difference; and the divide is higher than domestic norm.(2)By multiple factorsregression analysis, factors associated with anxiety were: economic status (p=0.044),treatment compliance (p=0.047), social support score(p=0.006), the severity ofdisease (p=0.023), inflammatory bowel disease quality of life(p=0.049) and chronicrecurrence have significant differences (p=0.027); but it had no statistical difference (p >0.05) with the patients’ age, gender, educational level, whether being glucocorticoidtreated or not. Risk factors for anxiety were chronic recurrence (OR=3.228), theseverity of disease (OR=4.039), nonadherence to treatment (OR=9.836); Protectionfactors for anxiety were social support score(OR=0.782), good economic conditions(OR=0.188), high quality of life (OR=0.366). Factors associated with depressionwere: active disease (p=0.017), treatment compliance (p=0.005), social supportscore (p=0.030),inflammatory bowel disease quality of life(p=0.022), the economicstatus(p=0.049);With age, sex, glucocorticoid treatment, cultural degree, course, theseverity of disease, chronic recurrence type had no significant statistical differences (p>0.05).Risk factors for depression were nonadherence to treatment (OR=6.117),activity(OR=10.496); Protection factors were social support score (OR=0.847), goodeconomic conditions (OR=0.215), high quality of life (OR=0.357).(3)By thestepwise multiple regression analysis, factors associated with anxiety scores were theseverity of disease (p=0.036), inflammatory bowel disease quality of life (p=0.015),social support score(p=0.023), the economic status (p=0.032), treatment compliance(p=0.00). Factors associated with depression scores were inflammatory bowel diseasequality of life (p=0.002), social support score (p=0.042), the economic status (p=0.003).Conclusions:(1)compared with the general population in China, patients with UC wereprone to anxiety, depression;(2)The severity of the disease, the type of disease andtreatment adherence with UC patients in active period and anxiety, depression and othermental abnormalities are closely related; It will be helpful to ease the anxiety,depression and other mental factors of UC patients with good economic conditions, highquality of life and social support.(3) Clinical work should focus on and evaluatecorrelative risk factors of anxiety and depression in patients with UC. Once the riskfactors are clear, psychological assessment should be given and early psychologicalintervention and treatment should be practiced according to the results of score.