Retrospective Analysis Of Factors Related To Infection During Chemotherapy In Patients With Lung Cancer

Objective: The objective is to study the relativity between the factors (age, gender,duration of hospitalization, chemotherapy regimens, lung cancer classification, invasiveoperation, smoking, white blood cell count, infection season, chinese medicinetreatment)and the infection during chemotherapy in patients with lung cancer so as toprovide clinic basis for preventing, monitoring and treatment of infections in them.Methods: According to inclusion criteria, the medical records of245patients with aclinical diagnosis of lung cancer hospitalized for chemotherapy during January2012~December2013are selected randomly.Then they are divided into infection group andnon infection group through retrospective survey method. SPSS statistics17.0statisticalsoftware were applicated to calculate the the relativity between the factors (age, gender,duration of hospitalization, chemotherapy regimens, lung cancer classification, invasiveoperation, smoking, white blood cell count, infection seasons, chinese medicinetreatments) and the infection during chemotherapy in patients with lung cancer.Results:1. Totally245patients with lung cancer were enrolled in this study, of which48caseswere infected, and the infection rate was19.6%.①Infection rate in groups of different age (<60years12%、≥60years27.2%) had significantdifference(p=0.006<0.05).②Infection rate in groups of different genders (male19.8%vs.female18.9%), had no significant difference (p=1>0.05).③Infection rate in groups of different timefor hospitalization (≤14d15.3%vs.＞14d32.2%)had significant difference(p=0.005<0.05).④Infection rate in groups of different general types (central type25.5%, peripheral type8.8%, diffusetype29.4%) was statistically significant difference (p=0.004<0.05).⑤Infection rate in groups ofdifferent chemotherapy regimens（≤2cycles6.0%vs.＞2cycles21.7%）had significant difference （p=0.002<0.05).⑥Infection rates in groups of non invasive operation(8.6%)and invasive operation(31.6%)patient had significant difference(p=0.000<0.05).⑦Infection rates in groups of nonsmoking (11.8%) and smoking patients(23.7%) was statistically significant difference (p=0.028<0.05).⑧Infection rates in groups of different white blood cell count（>3.0×109/L12.1%、≤3×109/L28.3%） had significant difference(p=0.002<0.05).⑨Infection rates in groups of different seasons(spring20%, summer16%,autumn18.9%,winter22%) had no statistically significant difference(p=0.835>0.05).⑩Infection rates in groups of Chinese medicine treatment(18.3%)and non Chinesemedicine treatment (21.4%) had no statistically significant difference (p=0.623>0.05).3. the Logistic multi-factor regression analysis equation created by Backwald LR method indicatedthat duration of hospitalization, chemotherapy regimens,lung cancer classification, invasive operation,smoking, white blood cell count were variables in the equation. And These could be regarded as theindependent risk factors of infection in patients with lung cancer.Conclusion:1.The factors of age,duration of hospitalization, chemotherapy regimens,lung cancerclassification, invasive operation, smoking, white blood cell count are closely related withthe infection during chemotherapy in patients with lung cancer. And there have not anyevidence indicate that the factors of age, gender, infection season, chinese medicinetreatment have any concern with it.2.As one of the factors, age are closely related with the infection during chemotherapy inpatients with lung cancer，but it can not be an independent risk factor. The factors ofduration of hospitalization, chemotherapy regimens,lung cancer classification, invasiveoperation, smoking, white blood cell count were the independent risk factors of infectionduring chemotherapy in patients with lung cancer.