The Expression Of TNF-α In Serum And Decidua Tissue Of Recurrent Spontaneousabortion Patients

Objective: To compare the level of expression of TNF-α in serum and deciduatissue of recurrent spontaneous abortion patients. To compare the level of expressionof TNF-α in serum and decidua tissue of different number of recurrent spontaneousabortion patients. To compare the level of expression of TNF-α on the impact ofprimary and secondary recurrent spontaneous abortion. Based on the determination ofTNF-α,this study provided a theoretical basis for clinical treatment of recurrentspontaneous abortion.Methods:76patients who due to recurrent spontaneous abortion accepted artificialabortion operation as a group, in the same period,100cases of normal earlypregnancy as control group, from January1,2013to March1,2014in Dalian MedicalUniversity affiliated Dalian City Maternity Hospital outpatient operating room. Thelevel of expression of TNF-α in serum and decidua tissue of two groups wasdetermined by ELISA method. At the same time, comparing the level of expression ofTNF-α in serum and decidua tissue of different number of recurrent spontaneousabortion patients and the impact of primary and secondary recurrent spontaneousabortion.Results:(1) The level of expression of TNF-α in serum of recurrent spontaneousabortion patients group was obviously higher than in normal pregnancy group, and therewas statistically significant difference (p=0.000). At the same time,the level ofexpression of TNF-α in decidua tissue of recurrent spontaneous abortion patients groupwas also obviously higher than in normal pregnancy group, and there was statisticallysignificant difference (p=0.000).(2) The level of expression of TNF-α in serum ofrecurrent spontaneous abortion patients compared with three times, there was nostatistically significant difference (p=0.200), and compared with more than3times, the difference was statistically significant (p=0.000). The comparison of above3times and3times,difference was statistically significant (p=0.018).(3) The level of expressionof TNF-α in decidua tissue of recurrent spontaneous abortion patients compared withthree times, there was no statistically significant difference (p=0.256), and comparedwith more than3times, the difference was statistically significant (p=0.001). Thecomparison of above3times and3times,difference was statistically significant (p=0.014).(4) The level of expression of TNF-α in serum of primary recurrent spontaneousabortion patients group was obviously lower than in secondary recurrent spontaneousabortion patients group, and there was statistically significant difference (p=0.000). Atthe same time,the level of expression of TNF-α in decidua tissue of secondary recurrentspontaneous abortion patients group was obviously higher than in primary recurrentspontaneous abortion patients group, and there was statistically significant difference (p=0.002).Conelusions:(1) The level of expression of TNF-α in serum and decidua tissue ofrecurrent spontaneous abortion patients is unusually high,which may lead to one of thecauses of RSA. The level of expression of TNF-α in serum and decidua tissue ofrecurrent spontaneous abortion patients is consistent. At the same time, the level ofexpression of TNF-α in serum can reflect the level of local tissue.(2)Three times ormore,TNF-α expression level is increased with the increased frequency of abortion,which may have important reference value on the pregnancy outcome,and can be usedas indicators of clinical predict RSA occurs.(3) The level of expression of TNF-α inserum and decidua tissue of secondary recurrent spontaneous abortion patients isobviously higher than in primary recurrent spontaneous abortion patients, whichsuggests that TNF-α has a greater influence on the occurrence of secondary RSA.