The Preliminary Study Of Double Exponential Diffusion Weighted Imaging In Acute Leukemia With Vertebral Bone Marrow After Treatment

Objective Study the normal volunteers, clinical bone marrow unalleviated leukemia patients, clinical bone marrow alleviated leukemia patients with lumbar double exponential diffusion weighted imaging and the regular diffusion weighted imaging, analyze the capacity of double exponential diffusion weighted imaging to evaluate tumor cells in acute leukemia with vertebral bone marrow infiltration, and investigate the value of double exponential diffusion weighted imaging in AL efficacy evaluation.Methods Ten cases of normal volunteers,8cases of clinical bone marrow unalleviated acute leukemia patients and8cases of patients with acute leukemia after treatment of clinical bone marrow remission were underwent GE1.5T lumbar sagittal double exponential diffusion weighted imaging (b=0,500,800,1000,800,1800,2000,2500s/mm2) and diffusion weighted imaging(b=500s/mm2), use function tool and MADC to measure multiple vertebral bone marrow ADC500,ADCslow, ADCfast, and f value.10normal volunteers (50vertebraes),8cases of acute leukemia non-remission patients (40vertebraes),8patients with bone marrow ease (40vertebraes).The research content:(1) the ADC500values were compareed between each group;(2) the ADC500values and the ADCslow value were compareed between each group;(3) the ADCslow、ADCfast、f values were compareed between each group. Quantitative data between groups were compared by using analysis of variance, the two independent samples t-test was used in the comparisons between the quantitative data. Results (1) ADC500has statistically significant differences between groups in volunteers, acute leukemia patients with marrow NR and acute leukemia with marrow CR, there was statistically significant difference (p<0.05) between normal volunteers and NR group,there was statistically significant (p<0.05) difference between normal volunteers and CR group, there was statistically significant (p<0.05) difference between NR and CR group(2) ADC500and ADCslow had statistical significance difference (p<0.05) within normal volunteers, acute leukemia NR group, acute leukemia CR group (3) ADCslow has no statistical differences between normal volunteers and patients with acute leukemia NR, acute leukemia CR groups, between normal and NR group p=0.04<0.05, the difference was statistically significant, between the CR and normal group p=0.899>0.05, there was no statistically significant difference, between NR and CR group p=0.039<0.05, the difference was statistically significant;ADCfast value has statistically significant differences between groups, between the NR and normal group p=0.186>0.05, there was no statistically significant difference, between the CR and normal group p=0.076>0.05, there was no statistically significant difference, between NR and CR group p=0.004<0.05, the difference was statistically significant;f value has statistical significance differences, between normal and NR between groups p=0.000<0.05, the difference was statistically significant, between the CR and normal group p=0.000<0.05, the difference was statistically significant, between NR and CR group p=0.205>0.05, there was no statistically significant difference.Conclusion (1) The application of double exponential diffusion weighted imaging in bone marrow is feasible, and the image quality of it could meet the requirements of diagnosis and measurement;(2) ADC500has certain reference value in the detection during the treatment of acute leukemia; ADCslow has certain reference value for the detection during the treatment of acute leukemia and is better than ADC500values in reflecting the load quantity of bone marrow cells;(3)The parameters acquired by double exponential diffusion weighted imaging reflected comprehensive intercellular physiological and pathological conditions leukemia patients, but it is needed to expand the sample size in the further research.