Correlation Between Serum Concentrations Of UcMGP And PIVKA-Ⅱ And Calcification Of Radial Artery In Patients With ESRD

Objective Observe the serum concentrations of uncarboxylated matrix Glaprotein (ucMGP) and calcification of radial artery in patients with end stagerenal disease (ESRD) to determine the correlation between them. Detect theprotein induced by vitamin K absence or antagonist-II (PIVKA-II) toestimate the level of vitamin K in patients with ESRD and determine thecorrelation between vitamin K deficiency and ucMGP level in patients withESRD as well as calcification of radial artery.Methods45patients with ESRD (experimental group) were recruitedfrom June2012to May2013in nephrology department of Anhui provincialhospital while30people in good health (control group) were included ascontrol. Radial arteries were partially excised from patients in experimentalgroup through forearm radial artery and cephalic vein anastomosis andstained to judge the degree of calcification. Fasting blood samples wererequired and tested via hematology analyzer and automatic biochemicalanalyzer to detect the concentration of hemoglobin (Hb), serum calcium(Ca), phosphorus (P) and albumin (ALB), while intact parathyroid hormone(iPTH) and C reactive protein (CRP) were detected throughelectrochemiluminescence and ucMGP and PIVKA-II through enzymelinked immunosorbent assay (ELISA). Results The concentration of Hb, Ca and ALB in experimental group waslower than that in control one, while the concentration of P, iPTH and CRPwas higher in experimental group. The serum concentration of ucMGP inexperimental group was (198.96±93.96) nmol/L, while that in controlgroup was (468.17±191.90) nmol/L, there was significant differencebetween them (P＜0.01). The serum concentration of PIVKA-II was(4.79±4.05) μg/L in experimental group, and (1.92±1.59) μg/L in controlone, there was significant difference between them (P＜0.01) as well.The calcification of radial arteries in experimental group located in tunicamedia. There were28cases without calcification in all45which (62.2%),12cases with slight calcification (26.7%) and5cases with severecalcification.Comparison of concentration of ucMGP and serum P innon-calcification, slight and severe calcification groups indicatedsignificant difference (P＜0.01). There was significant difference of theserum PIVKA-II between severe calcification group and slight one (P＜0.05).Spearman correlation analysis indicated negative correlation betweencalcification and ucMGP (r=-0.64，P＜0.05), and positive correlationcalcification and serum P, iPTH and CRP. Pearson correlation analysisindicated negative correlation between ucMGP and serum P (rs=-0.31，P＜0.05), and there was no obvious correlation between ucMGP andPIVKA-II.Conclusion The serum concentration of ucMGP in patients with ESRD waslower than that in healthy people, and was associated with radialcalcification. The serum concentration of PIVKA-II in patients with ESRDaccompanying vitamin K insufficiency was higher than that in healthypeople. There was no significant difference between serum concentration of ucMGP and PIVKA-II in patients with ESRD.