The Relationship Between Vitamin D Deficiency And Depression In Patients With Chronic Kidney Disease

Objective:To investigate the prevalence of depression and vitamin D deficiency in patients with chronic kidney disease.To explore the relationship between vitamin D deficiency and depression in patients with CKD.Methods:CKD patients diagnosed and treated in the Department of Nephrology of Hunan Provincial People's Hospital from August 2017 to December 2017 were selected.According to the inclusion and exclusion criteria,112 subjects were enrolled in this study.Collect general clinical information of patients:age,sex,primary disease,height,weight,body mass index,occupational status,education status,economic status,alcohol behavior,smoking status,and serum creatinine(SCR),urea nitrogen(BUN),glomerular filtration rate(EGFR),hemoglobin(HB),albumin(Alb),cholesterol(TG),Blood sugar(BS),vitamin D,and past history of hypertension,diabetes mellitus,whether to enter dialysis.Hamilton Depression Scale(HAMD)questionnaires was used in all subjects to assess whether the subjects had depression or not.According to the K/DOQI guidelines,Vitamin D deficiency is defined as 10 ng/ml?25(OH)D<20 ng/ml.Through data analysis,To investigate the prevalence of depression and vitamin D deficiency in patients in CKD patients.All subjects were divided into depression group(HAMD score? 17)and non-depression group(HAMD score<17).To compare the general data and biochemical indexes of depressive group and non depressive group,The association between vitamin D deficiency and depression was assessed by binary logistic regression analysis.Result:1.The prevalence rate of depression in 112 patients with CKD was 37.5%(n=42)2.The mean vitamin D level in 112 patients with CKD was 21.04±6.97 ng/nl,and the incidence of vitamin D deficiency was 47.32%(n?53).3.The number of smokers,low-income persons,and dialysis patients in the depression group were significantly higher than those in the non-depression group,while the employment numbers were significantly lower than those in the non-depression group(P<0.05).The level of vitamin D,hemoglobin,and glomerular filtration rate were significantly lower in the depression group than in the non-depression group.Creatinine was significantly higher in the depression group than in the non-depression group(P<0.05).4.Binary Logistic regression analysis showed that vitamin D deficiency(B=0.880,P<0.05)and anemia(B=0.964,P<0.05)were independent risk factors for depression in CKD patients.Conclusion:1.Depression and vitamin D deficiency are very common in patients with CKD.2.Vitamin D deficiency is an independent risk factor for depression in CKD patients.Correcting vitamin D deficiency may help to prevent depression in CKD patients.