Study On The Correlation Of Estrogen Level And High-sensitivity C-reactive Protein, Blood Homocysteine, Fibrinogen In Postmenopausal Women With Hypertension

BackgroundHypertension is one of the popular cardiovascular diseases in clinic and a majorrisk factor for cardiovascular events. With the development of the economy and theimprovement of people’s living standards, as well as the increase of the stress of lifein today’s society, the prevalence rate of hypertension is also increasing, and moreand more patients are to be younger. The incidence of hypertension in the world ismore than25%, and increases gradually along with the growth of the age. At the ageof35-44years old, the prevalence of hypertension was significantly below their malecounterparts. But in postmenopausal women, this phenomenon made a change, Theincidence of high blood pressure in women starts rising. Research shows that in morethan75-year-old crowd, the prevalence of hypertension is diffierent, and women’sare higher than their male counterparts. Before and after the menopause, thedifference in the incidence of high blood pressure in women is significant meaning.Clinical epidemiological investigation shows that menopause may be related to theincidence of hypertension, and it in mainly for systolic blood pressure. Comparedwith premenopausal and postmenopausal or perimenopausal women, the systolicblood pressure is increased about4-5mmHg. And there is also a research shows that compared with the women of premenopausal and the menopausal transition,postmenopausal women’s systolic blood pressure increases5mmHg roughly every10years. In the United States, according to a cohort study, the proportion ofpostmenopausal women with hypertension who accepted antihypertensive treatmentis not high, and the proportion of patient’s who’s blood pressure can reach the basicstandards is lower. The national health and nutrition’s survey also confirmed thatcardiovascular risk in postmenopausal women is significantly increased.It suggeststhat high blood pressure control in older women is not very ideal. The hormone levelof postmenopausal women changes, and the level of estrogenic hormone ofperimenopausal women begin to reduce. The ratio of estrogen and androgen getsdown, and androgen level is relatively higher. These changes can lead to vascularendothelial dysfunction, increase sympathetic nervous system activity, oxidativestress, the activity of renin-angiotensin system, salt sensitivity, etc.. These can affectblood pressure. But the related mechanism in postmenopausal women is still notperfect. Heredity, age, obesity, blood sugar, blood fat, smoking, drinking, mentalstress and other risk factors cannot well explain the development of women’shypertension. At present some new risk factors gradually aroused people’s attention,such as estradiol, high-sensitivity c-reactive protein, blood, fibrinogen andhomocysteine, but its specific pathogenesis and their relations are not very clear.ObjectiveTo explore the connection between the decrease of estrogen level and thehypertension of postmenopausal women. And to research the relationship betweenestrogen and high-sensitivity c-reactive protein, homocysteine, fibrinogen, and theireffects in the process of development in high blood pressure. And so to further clarifythe pathogenesis of hypertension in postmenopausal women.MethodsSelecting130cases of hospitalized patients, and these women menopause atleast more than one year and aged55-75years old.70postmenopausal women with hypertension were recruited to participate the study and60postmenopausal womenwithout hypertension as control. We census their age, age at menopause, fasting bloodglucose, blood high-sensitivity c-reactive protein, homocysteine, triglyceride,cholesterol, low density cholesterol, fibrinogen, estradiol, progesterone andtestosterone. We sorts through the resulting data and uses statistical methods toanalyze.Results1. The fasting plasma glucose, high-sensitivity c-reactive protein, homocysteine,triglyceride, fibrinogen were incread in hypertension group compared to the non-hypertension group, and the estradiol of hypertension group was significantly lowerthan the non-hypertension group(P<0.01).2. The progesterone and testosterone were no significant differenc between thehypertension group and the non-hypertension group(P>0.05).3. The estradiol was negative correlated with age(r=-0.736), fasting plasmaglucose (r=-0.279), high-sensitivity c-reactive protein (r=-0.324), homocysteine(r=-0.662), triglyceride (r=-0.234), low density cholesterol(r=-0.289), fibrinogen(r=-0.655)(P<0.05).4. The high-sensitivity c-reactive protein、homocysteine and fibrinogen wereinfluencing factors of estradiol of postmenopausal women with hypertension(P<0.05).Conclusion1. The reduce of estradiol levels, the increased of high-sensitivity c-reactiveprotein、homocysteine、 fibrinogen and glucose and lipid metabolism disorder arerisk factors for hypertension among postmenopausal women.2. Estradiol level of postmenopausal women with high blood pressure is relatedto age, blood fat, blood sugar, high-sensitivity c-reactive protein, blood homocysteineand fibrinogen levels.3. It illustrates that the inflammation and the activation of blood clotting system may be associated with estrogen levels decline, they may jointly participate in thedevelopment process of hypertension among postmenopausal women.