The Relationship Between Helicobacter Pylori Infection And Chemotherapy-induced Nausea And Vomiting

BackgroundCancer is one of the three human killers in recent years, with the deterioration ofpeople’s living environment, accelerated pace of life and the bad living habits, theincidence of various cancers showed arising trend, and more and more cancers tend tobe younger, it is a serious threat to people’s physical and mental health.Chemotherapy is one of the main means in the treatment of various malignant tumorsunder the existing treatment conditions, especially in China, the majority of cancerpatients are middle and late chemotherapies becomes more important when found.But chemotherapy drugs often cause greater harm to human when exert anti-tumoreffect, the most common side effects are nausea and vomiting, adding to thepsychological burden of patients.Recently, highly selective5-HT3receptorantagonists may be more effective for prevention and treatment of various causesnausea and vomiting. However, in clinical observation, a part of the patient’sgastrointestinal reactions can not achieve satisfactory control, affecting the quality oflife of patients and the confidence of the next chemotherapy cycle.Studies have shown that relationship between HP and chronic gastritis, pepticulcer disease, gastric mucosa-associated lymphoid tissue lymphoma, and gastriccancer and other gastrointestinal diseases are close. But so far, studies on relationshipbetween HP infection and chemotherapy-induced gastrointestinal toxicity have hadfewer reports at home and abroad. ObjectiveTo explore the relationship between H. pylori (HP) infection in ClinicalOncology patients and chemotherapy-induced nausea and vomitingMethodsSelect152untreated and malignant tumor cases, from July,2012to September,2013at the First Affiliated Hospital of Zhengzhou University, oncology, HP isdetected by13C breath test; Triple therapy is used for HP eradication, to understandchanges in the chemotherapy-induced nausea and vomiting before and after HPeradication.ResultsIn the152malignant tumor cases, the HP positive rate is64.50%（98/152),nausea and vomiting degree among cancer patients with Helicobacter Pylori infectionwas higher than uninfected patients. Differences between severe nausea, vomiting（λ2=14.81，P=0.011）and mild nausea, vomiting（λ2=6.49，P=0.032）were statisticallysignificant; the eradication rate of98HP-positive patients is87.76%（86/98); In the86HP-positive cases, after HP eradication incidence of severe nausea and vomitingcaused by chemotherapy declines from63.95%（55/86）to33.72%（29/86), thedifference is significant（λ2=6.119, P=0.013).ConclusionIn cancer patients, Helicobacter pylori infection is closely related tochemotherapy-induced nausea and vomiting; H. pylori infection may be one of themain factors aggravating chemotherapy-induced nausea and vomiting; The radicalcure of HP can effectively improve chemotherapy-induced nausea and vomiting andother gastrointestinal reactions.